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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4828
Target Type SINGLE PROTEIN
Preferred Name Synaptic vesicular amine transporter
Synonyms Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | Vesicular amine transporter 2 | Vmat2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc18 family of vesicular amine transporters

Target Components

Component Description Relationship Accession
Synaptic vesicular amine transporter SINGLE PROTEIN Q01827

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005887 (integral component of plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0030672 (synaptic vesicle membrane)
GO:0031045 (dense core granule)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043679 (axon terminus)
GO:0044297 (cell body)
GO Molecular Function GO:0005275 (amine transmembrane transporter activity)
GO:0008144 (drug binding)
GO:0015222 (serotonin transmembrane transporter activity)
GO:0015238 (drug transmembrane transporter activity)
GO:0019899 (enzyme binding)
GO:0031072 (heat shock protein binding)
GO Biological Process GO:0001975 (response to amphetamine)
GO:0006810 (transport)
GO:0006836 (neurotransmitter transport)
GO:0006837 (serotonin transport)
GO:0006855 (drug transmembrane transport)
GO:0007268 (chemical synaptic transmission)
GO:0007568 (aging)
GO:0009635 (response to herbicide)
GO:0010038 (response to metal ion)
GO:0010043 (response to zinc ion)
GO:0015842 (aminergic neurotransmitter loading into synaptic vesicle)
GO:0015844 (monoamine transport)
GO:0015893 (drug transport)
GO:0030073 (insulin secretion)
GO:0032456 (endocytic recycling)
GO:0035690 (cellular response to drug)
GO:0042220 (response to cocaine)
GO:0042493 (response to drug)
GO:0042593 (glucose homeostasis)
GO:0042594 (response to starvation)
GO:0051412 (response to corticosterone)
GO:0051589 (negative regulation of neurotransmitter transport)
GO:0055085 (transmembrane transport)
GO:0071242 (cellular response to ammonium ion)

Target Cross References - Protein

canSAR Q01827
Guide to Pharmacology 1012
UniProt Q01827 Q9QVP1

Target Cross References - Domain

InterPro IPR004734 (Multidrug-R.)
IPR011701 (MFS.)
IPR020846 (MFS_dom.)
Pfam PF07690 (MFS_1)
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