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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4804
Target Type SINGLE PROTEIN
Preferred Name Dual specificity phosphatase Cdc25B
Synonyms CDC25B | CDC25HU2 | Dual specificity phosphatase Cdc25B | M-phase inducer phosphatase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine/tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
M-phase inducer phosphatase 2 SINGLE PROTEIN P30305

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101224
Ensembl ENSG00000101224
GO Cellular Component GO:0000922 (spindle pole)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000278 (mitotic cell cycle)
GO:0001556 (oocyte maturation)
GO:0006468 (protein phosphorylation)
GO:0006470 (protein dephosphorylation)
GO:0007049 (cell cycle)
GO:0007144 (female meiosis I)
GO:0008284 (positive regulation of cell proliferation)
GO:0032467 (positive regulation of cytokinesis)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0051301 (cell division)
GO:1902751 (positive regulation of cell cycle G2/M phase transition)
Wikipedia CDC25B

Target Cross References - Protein

canSAR P30305
Human Protein Atlas ENSG00000101224
IntAct P30305
Open Targets ENSG00000101224
PharmGKB PA26260
Reactome R-HSA-69273 (Cyclin A/B1/B2 associated events during G2/M transition.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
UniProt D3DVY1 D3DVY2 D3DVY3 D3DVY4 O43551 P30305 Q13971 Q5JX77 Q6RSS1 Q9BRA6

Target Cross References - Domain

InterPro IPR000751 (MPI_Phosphatase.)
IPR001763 (Rhodanese-like_dom.)
IPR036873 (Rhodanese-like_dom_sf.)
Pfam PF00581 (Rhodanese)
PF06617 (M-inducer_phosp)

Target Cross References - Structure

PDBe 1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
CREDO 1CWR 1CWS 1CWT 1QB0 1YM9 1YMD 1YMK 1YML 1YS0 2A2K 2IFD 2IFV 2UZQ 3FQT 3FQU 4WH7 4WH9
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