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Target Report Card

Target Name and Classification

Target ID CHEMBL4777
Preferred Name Neuropeptide Y receptor type 1
Synonyms NPY1-R | NPY1R | NPYR | NPYY1 | Neuropeptide Y receptor type 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neuropeptide y receptor

Target Components

Component Description Relationship Accession
Neuropeptide Y receptor type 1 SINGLE PROTEIN P25929

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164128
Ensembl ENSG00000164128
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001601 (peptide YY receptor activity)
GO:0001602 (pancreatic polypeptide receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004983 (neuropeptide Y receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0003151 (outflow tract morphogenesis)
GO:0006006 (glucose metabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007626 (locomotory behavior)
GO:0007631 (feeding behavior)
GO:0008015 (blood circulation)
GO:0008217 (regulation of blood pressure)
GO:0019233 (sensory perception of pain)
GO:0040014 (regulation of multicellular organism growth)
Wikipedia Neuropeptide_Y_receptor_Y1

Target Cross References - Protein

canSAR P25929
Human Protein Atlas ENSG00000164128
IntAct P25929
Guide to Pharmacology 305
Open Targets ENSG00000164128
PharmGKB PA258
Pharos P25929 (Tchem)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B2R6H5 P25929

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000351 (NPY1_rcpt.)
IPR000611 (NPY_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)