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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4769
Target Type SINGLE PROTEIN
Preferred Name Geranylgeranyl pyrophosphate synthetase
Synonyms (2E,6E)-farnesyl diphosphate synthase | Dimethylallyltranstransferase | Farnesyl diphosphate synthase | Farnesyltranstransferase | GGPP synthase | GGPPSase | GGPS1 | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthase | Geranyltranstransferase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Geranylgeranyl pyrophosphate synthase SINGLE PROTEIN O95749

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152904
Ensembl ENSG00000152904
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004161 (dimethylallyltranstransferase activity)
GO:0004311 (farnesyltranstransferase activity)
GO:0004337 (geranyltranstransferase activity)
GO:0005515 (protein binding)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006695 (cholesterol biosynthetic process)
GO:0006720 (isoprenoid metabolic process)
GO:0008299 (isoprenoid biosynthetic process)
GO:0033384 (geranyl diphosphate biosynthetic process)
GO:0033386 (geranylgeranyl diphosphate biosynthetic process)
GO:0045337 (farnesyl diphosphate biosynthetic process)
GO:0045540 (regulation of cholesterol biosynthetic process)
Wikipedia GGPS1

Target Cross References - Protein

canSAR O95749
Human Protein Atlas ENSG00000152904
IntAct O95749
Guide to Pharmacology 643
Open Targets ENSG00000152904
PharmGKB PA28661
Reactome R-HSA-191273 (Cholesterol biosynthesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
UniProt A8MVQ8 O95749 Q5T2C8 Q6NW19

Target Cross References - Domain

InterPro IPR000092 (Polyprenyl_synt.)
IPR008949 (Isoprenoid_synthase_dom_sf.)
IPR033749 (Polyprenyl_synt_CS.)
Pfam PF00348 (polyprenyl_synt)

Target Cross References - Structure

PDBe 2Q80
CREDO 2Q80
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