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Target Report Card

Target Name and Classification

Target ID CHEMBL4714
Preferred Name Pyrimidinergic receptor P2Y6
Synonyms P2RY6 | P2Y purinoceptor 6 | P2Y6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > purine receptor

Target Components

Component Description Relationship Accession
P2Y purinoceptor 6 SINGLE PROTEIN Q15077

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171631
Ensembl ENSG00000171631
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO:0045029 (UDP-activated nucleotide receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0030321 (transepithelial chloride transport)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
GO:0071380 (cellular response to prostaglandin E stimulus)
GO:0071407 (cellular response to organic cyclic compound)
Wikipedia P2RY6

Target Cross References - Protein

canSAR Q15077
Human Protein Atlas ENSG00000171631
IntAct Q15077
Guide to Pharmacology 326
Open Targets ENSG00000171631
PharmGKB PA32872
Pharos Q15077 (Tchem)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-417957 (P2Y receptors.)
UniProt Q15077 Q15754

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001973 (P2Y6_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)