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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4685
Target Type SINGLE PROTEIN
Preferred Name Indoleamine 2,3-dioxygenase
Synonyms IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-dioxygenase 1 | Indoleamine-pyrrole 2,3-dioxygenase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Indoleamine 2,3-dioxygenase 1 SINGLE PROTEIN P14902

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545369 EPACADOSTAT Indoleamine 2,3-dioxygenase inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131203
Ensembl ENSG00000131203
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030485 (smooth muscle contractile fiber)
GO:0032421 (stereocilium bundle)
GO Molecular Function GO:0004833 (tryptophan 2,3-dioxygenase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0033754 (indoleamine 2,3-dioxygenase activity)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0002376 (immune system process)
GO:0002534 (cytokine production involved in inflammatory response)
GO:0002666 (positive regulation of T cell tolerance induction)
GO:0002678 (positive regulation of chronic inflammatory response)
GO:0002830 (positive regulation of type 2 immune response)
GO:0006569 (tryptophan catabolic process)
GO:0006954 (inflammatory response)
GO:0007565 (female pregnancy)
GO:0019441 (tryptophan catabolic process to kynurenine)
GO:0022900 (electron transport chain)
GO:0032496 (response to lipopolysaccharide)
GO:0032693 (negative regulation of interleukin-10 production)
GO:0032735 (positive regulation of interleukin-12 production)
GO:0033555 (multicellular organismal response to stress)
GO:0034276 (kynurenic acid biosynthetic process)
GO:0036269 (swimming behavior)
GO:0042130 (negative regulation of T cell proliferation)
GO:0043065 (positive regulation of apoptotic process)
GO:0046006 (regulation of activated T cell proliferation)
GO:0055114 (oxidation-reduction process)
GO:0070233 (negative regulation of T cell apoptotic process)
GO:0070234 (positive regulation of T cell apoptotic process)
Wikipedia Indoleamine_2,3-dioxygenase

Target Cross References - Protein

canSAR P14902
Human Protein Atlas ENSG00000131203
IntAct P14902
Guide to Pharmacology 2829
Open Targets ENSG00000131203
PharmGKB PA29869
Reactome R-HSA-71240 (Tryptophan catabolism.)
UniProt E5RGR8 F6M9T7 P14902 Q540B4

Target Cross References - Domain

InterPro IPR000898 (Indolamine_dOase.)
IPR037217 (Trp/Indoleamine_2_3_dOase-like.)
Pfam PF01231 (IDO)

Target Cross References - Structure

PDBe 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6F0A
CREDO 2D0T 2D0U 4PK5 4PK6 4U72 4U74 5EK2 5EK3 5EK4 5ETW 5WHR 5WMU 5WMV 5WMW 5WMX 5WN8 5XE1 6F0A
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