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Target Report Card

Target Name and Classification

Target ID CHEMBL4662
Preferred Name Proteasome Macropain subunit MB1
Synonyms LMPX | MB1 | Macropain epsilon chain | Multicatalytic endopeptidase complex epsilon chain | PSMB5 | Proteasome chain 6 | Proteasome epsilon chain | Proteasome subunit MB1 | Proteasome subunit X | Proteasome subunit beta type-5 | X
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > threonine protease > threonine protease pbt clan > threonine protease t1a subfamily

Target Components

Component Description Relationship Accession
Proteasome subunit beta type-5 SINGLE PROTEIN P28074

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831201 20S proteosome PROTEIN COMPLEX
CHEMBL3885625 Proteasome subunit beta type-1/beta type-5 PROTEIN FAMILY
CHEMBL2364701 26S proteosome PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100804
Ensembl ENSG00000100804
GO Cellular Component GO:0000502 (proteasome complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005839 (proteasome core complex)
GO:0019774 (proteasome core complex, beta-subunit complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004298 (threonine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000209 (protein polyubiquitination)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002479 (antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)
GO:0006508 (proteolysis)
GO:0006521 (regulation of cellular amino acid metabolic process)
GO:0006979 (response to oxidative stress)
GO:0010972 (negative regulation of G2/M transition of mitotic cell cycle)
GO:0016032 (viral process)
GO:0016579 (protein deubiquitination)
GO:0031145 (anaphase-promoting complex-dependent catabolic process)
GO:0031146 (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0038061 (NIK/NF-kappaB signaling)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043488 (regulation of mRNA stability)
GO:0043687 (post-translational protein modification)
GO:0050852 (T cell receptor signaling pathway)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0055085 (transmembrane transport)
GO:0060071 (Wnt signaling pathway, planar cell polarity pathway)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0070498 (interleukin-1-mediated signaling pathway)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1902036 (regulation of hematopoietic stem cell differentiation)
Wikipedia PSMB5

Target Cross References - Protein

canSAR P28074
Human Protein Atlas ENSG00000100804
IntAct P28074
Guide to Pharmacology 2406
Open Targets ENSG00000100804
PharmGKB PA33887
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-1234176 (Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.)
R-HSA-1236974 (ER-Phagosome pathway.)
R-HSA-1236978 (Cross-presentation of soluble exogenous antigens (endosomes).)
R-HSA-174084 (Autodegradation of Cdh1 by Cdh1:APC/C.)
R-HSA-174113 (SCF-beta-TrCP mediated degradation of Emi1.)
R-HSA-174154 (APC/C:Cdc20 mediated degradation of Securin.)
R-HSA-174178 (APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.)
R-HSA-174184 (Cdc20:Phospho-APC/C mediated degradation of Cyclin A.)
R-HSA-180534 (Vpu mediated degradation of CD4.)
R-HSA-180585 (Vif-mediated degradation of APOBEC3G.)
R-HSA-187577 (SCF(Skp2)-mediated degradation of p27/p21.)
R-HSA-195253 (Degradation of beta-catenin by the destruction complex.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-211733 (Regulation of activated PAK-2p34 by proteasome mediated degradation.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-349425 (Autodegradation of the E3 ubiquitin ligase COP1.)
R-HSA-350562 (Regulation of ornithine decarboxylase (ODC).)
R-HSA-382556 (ABC-family proteins mediated transport.)
R-HSA-450408 (AUF1 (hnRNP D0) binds and destabilizes mRNA.)
R-HSA-4608870 (Asymmetric localization of PCP proteins.)
R-HSA-4641257 (Degradation of AXIN.)
R-HSA-4641258 (Degradation of DVL.)
R-HSA-5358346 (Hedgehog ligand biogenesis.)
R-HSA-5362768 (Hh mutants that don't undergo autocatalytic processing are degraded by ERAD.)
R-HSA-5607761 (Dectin-1 mediated noncanonical NF-kB signaling.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5610780 (Degradation of GLI1 by the proteasome.)
R-HSA-5610783 (Degradation of GLI2 by the proteasome.)
R-HSA-5610785 (GLI3 is processed to GLI3R by the proteasome.)
R-HSA-5632684 (Hedgehog 'on' state.)
R-HSA-5658442 (Regulation of RAS by GAPs.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-5676590 (NIK-->noncanonical NF-kB signaling.)
R-HSA-5678895 (Defective CFTR causes cystic fibrosis.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-5689603 (UCH proteinases.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-68827 (CDT1 association with the CDC6:ORC:origin complex.)
R-HSA-68949 (Orc1 removal from chromatin.)
R-HSA-69017 (CDK-mediated phosphorylation and removal of Cdc6.)
R-HSA-69229 (Ubiquitin-dependent degradation of Cyclin D1.)
R-HSA-69481 (G2/M Checkpoints.)
R-HSA-69601 (Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.)
R-HSA-8852276 (The role of GTSE1 in G2/M progression after G2 checkpoint.)
R-HSA-8854050 (FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.)
R-HSA-8939236 (RUNX1 regulates transcription of genes involved in differentiation of HSCs.)
R-HSA-8939902 (Regulation of RUNX2 expression and activity.)
R-HSA-8941858 (Regulation of RUNX3 expression and activity.)
R-HSA-8948751 (Regulation of PTEN stability and activity.)
R-HSA-8951664 (Neddylation.)
R-HSA-9010553 (Regulation of expression of SLITs and ROBOs.)
R-HSA-9020702 (Interleukin-1 signaling.)
R-HSA-983168 (Antigen processing: Ubiquitination & Proteasome degradation.)
UniProt B2R4N9 B4DUM9 D3DS43 E9PAV2 P28074 Q16242 Q6PEW2 Q7Z3B5 Q86T01 Q9TNN9

Target Cross References - Domain

InterPro IPR000243 (Pept_T1A_subB.)
IPR001353 (Proteasome_sua/b.)
IPR016050 (Proteasome_bsu_CS.)
IPR023333 (Proteasome_suB-type.)
IPR029055 (Ntn_hydrolases_N.)
IPR037558 (Proteasome_beta_5.)
Pfam PF00227 (Proteasome)

Target Cross References - Structure

PDBe 4R3O 4R67 5L5W 5L5X 5L5Y 5L5Z 5L60 5L61 5L62 5L63 5L64 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7
CREDO 4R3O 4R67 5L5W 5L5X 5L5Y 5L5Z 5L60 5L61 5L62 5L63 5L64 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7