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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4641
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated T-type calcium channel alpha-1G subunit
Synonyms CACNA1G | Cav3.1c | KIAA1123 | NBR13 | Voltage-dependent T-type calcium channel subunit alpha-1G | Voltage-gated calcium channel subunit alpha Cav3.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent T-type calcium channel subunit alpha-1G SINGLE PROTEIN O43497

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363032 Voltage-gated calcium channel PROTEIN COMPLEX GROUP
CHEMBL2362995 Voltage-gated T-type calcium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000006283
Ensembl ENSG00000006283
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005262 (calcium channel activity)
GO:0008332 (low voltage-gated calcium channel activity)
GO:0086056 (voltage-gated calcium channel activity involved in AV node cell action potential)
GO:0086059 (voltage-gated calcium channel activity involved SA node cell action potential)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001508 (action potential)
GO:0002027 (regulation of heart rate)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0010045 (response to nickel cation)
GO:0019228 (neuronal action potential)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0045956 (positive regulation of calcium ion-dependent exocytosis)
GO:0055085 (transmembrane transport)
GO:0060371 (regulation of atrial cardiac muscle cell membrane depolarization)
GO:0070509 (calcium ion import)
GO:0070588 (calcium ion transmembrane transport)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086010 (membrane depolarization during action potential)
GO:0086015 (SA node cell action potential)
GO:0086016 (AV node cell action potential)
GO:0086018 (SA node cell to atrial cardiac muscle cell signalling)
GO:0086027 (AV node cell to bundle of His cell signaling)
GO:0086045 (membrane depolarization during AV node cell action potential)
GO:0086046 (membrane depolarization during SA node cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
Wikipedia CACNA1G

Target Cross References - Protein

canSAR O43497
Human Protein Atlas ENSG00000006283
IntAct O43497
Guide to Pharmacology 535
Open Targets ENSG00000006283
PharmGKB PA381
Pharos O43497 (Tclin)
Reactome R-HSA-419037 (NCAM1 interactions.)
UniProt D6RA64 E7EPR0 O43497 O43498 O94770 Q19QY8 Q19QY9 Q19QZ0 Q19QZ1 Q19QZ2 Q19QZ3 Q19QZ4 Q19QZ5 Q19QZ6 Q19QZ7 Q19QZ8 Q19QZ9 Q19R00 Q19R01 Q19R02 Q19R03 Q19R04 Q19R05 Q19R06 Q19R07 Q19R08 Q19R09 Q19R10 Q19R11 Q19R12 Q19R13 Q19R15 Q19R16 Q19R17 Q19R18 Q2TAC4 Q9NYU4 Q9NYU5 Q9NYU6 Q9NYU7 Q9NYU8 Q9NYU9 Q9NYV0 Q9NYV1 Q9UHN9 Q9UHP0 Q9ULU6 Q9UNG7 Q9Y5T2 Q9Y5T3

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005445 (VDCC_T_a1.)
IPR005821 (Ion_trans_dom.)
IPR027359 (Volt_channel_dom_sf.)
IPR030154 (VDCC_T_a1G.)
Pfam PF00520 (Ion_trans)
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