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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4618
Target Type SINGLE PROTEIN
Preferred Name Leukotriene A4 hydrolase
Synonyms LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Leukotriene A-4 hydrolase SINGLE PROTEIN P09960

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111144
Ensembl ENSG00000111144
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0070006 (metalloaminopeptidase activity)
GO:0004301 (epoxide hydrolase activity)
GO:0004463 (leukotriene-A4 hydrolase activity)
GO:0044822 (poly(A) RNA binding)
GO:0004177 (aminopeptidase activity)
GO:0042277 (peptide binding)
GO:0008233 (peptidase activity)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0043171 (peptide catabolic process)
GO:0060509 (Type I pneumocyte differentiation)
GO:0019369 (arachidonic acid metabolic process)
GO:0044281 (small molecule metabolic process)
GO:0006954 (inflammatory response)
GO:0019370 (leukotriene biosynthetic process)
GO:0006508 (proteolysis)
GO:0006691 (leukotriene metabolic process)
GO:0010043 (response to zinc ion)
GO:0043434 (response to peptide hormone)

Target Cross References - Protein

canSAR P09960
Human Protein Atlas ENSG00000111144
IntAct P09960
Guide to Pharmacology 1395 (Leukotriene A4 hydrolase)
PharmGKB PA24345
UniProt B4DNQ9 Q6IAT6 P09960 Q9UCT7

Target Cross References - Domain

InterPro IPR012777 (Leukotriene_A4_hydrolase.)
IPR014782 (Peptidase_M1_N.)
IPR015211 (Peptidase_M1_C.)
IPR001930 (Peptidase_M1.)
IPR016024 (ARM-type_fold.)
Pfam PF01433 (Peptidase_M1)
PF09127 (Leuk-A4-hydro_C)

Target Cross References - Structure

PDBe 1HS6 2R59 3CHR 3FUM 1GW6 3FU3 3FUF 3FUH 1H19 2VJ8 3B7R 3FTW 3FTY 3FU5 3FUJ 3FH5 3FH8 3FTX 3FTZ 3FU6 3FUD 3FUN 3U9W 4L2L More...
CREDO 1HS6 2R59 3CHR 3FUM 1GW6 3FU3 3FUF 3FUH 1H19 2VJ8 3B7R 3FTW 3FTY 3FU5 3FUJ 3FH5 3FH8 3FTX 3FTZ 3FU6 3FUD 3FUN 3U9W 4L2L More...
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