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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4618
Target Type SINGLE PROTEIN
Preferred Name Leukotriene A4 hydrolase
Synonyms LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Leukotriene A-4 hydrolase SINGLE PROTEIN P09960

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111144
Ensembl ENSG00000111144
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0004301 (epoxide hydrolase activity)
GO:0004463 (leukotriene-A4 hydrolase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0044822 (poly(A) RNA binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006508 (proteolysis)
GO:0006691 (leukotriene metabolic process)
GO:0006954 (inflammatory response)
GO:0010043 (response to zinc ion)
GO:0019370 (leukotriene biosynthetic process)
GO:0043171 (peptide catabolic process)
GO:0043434 (response to peptide hormone)
GO:0060509 (Type I pneumocyte differentiation)

Target Cross References - Protein

canSAR P09960
Human Protein Atlas ENSG00000111144
IntAct P09960
Guide to Pharmacology 1395
Open Targets ENSG00000111144
PharmGKB PA24345
Reactome R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B4DNQ9 F8VV40 P09960 Q6IAT6 Q9UCT7

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR012777 (Leukotriene_A4_hydrolase.)
IPR014782 (Peptidase_M1_N.)
IPR015211 (Peptidase_M1_C.)
IPR016024 (ARM-type_fold.)
IPR034015 (M1_LTA4H.)
Pfam PF01433 (Peptidase_M1)
PF09127 (Leuk-A4-hydro_C)

Target Cross References - Structure

PDBe 1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX More...
CREDO 1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX More...
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