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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4581
Target Type SINGLE PROTEIN
Preferred Name Kinesin-like protein 1
Synonyms EG5 | KIF11 | KNSL1 | Kinesin-like protein 1 | Kinesin-like protein KIF11 | Kinesin-like spindle protein HKSP | Kinesin-related motor protein Eg5 | TR-interacting protein 5 | TRIP-5 | TRIP5 | Thyroid receptor-interacting protein 5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Kinesin-like protein KIF11 SINGLE PROTEIN P52732

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2105661 LITRONESIB Kinesin-like protein 1 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138160
Ensembl ENSG00000138160
GO Cellular Component GO:0000922 (spindle pole)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005871 (kinesin complex)
GO:0005874 (microtubule)
GO:0005876 (spindle microtubule)
GO:0016020 (membrane)
GO:0072686 (mitotic spindle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003777 (microtubule motor activity)
GO:0005524 (ATP binding)
GO:0008017 (microtubule binding)
GO:0008574 (ATP-dependent microtubule motor activity, plus-end-directed)
GO:0019901 (protein kinase binding)
GO:0044877 (macromolecular complex binding)
GO Biological Process GO:0000278 (mitotic cell cycle)
GO:0006890 (retrograde vesicle-mediated transport, Golgi to ER)
GO:0007018 (microtubule-based movement)
GO:0007049 (cell cycle)
GO:0007051 (spindle organization)
GO:0007052 (mitotic spindle organization)
GO:0007059 (chromosome segregation)
GO:0007100 (mitotic centrosome separation)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0046602 (regulation of mitotic centrosome separation)
GO:0051225 (spindle assembly)
GO:0051301 (cell division)
GO:0090307 (mitotic spindle assembly)
Wikipedia Kinesin_family_member_11

Target Cross References - Protein

canSAR P52732
CGD Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation, autosomal dominant
Human Protein Atlas ENSG00000138160
IntAct P52732
Guide to Pharmacology 2788
Open Targets ENSG00000138160
PharmGKB PA30177
Reactome R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-6811434 (COPI-dependent Golgi-to-ER retrograde traffic.)
R-HSA-983189 (Kinesins.)
UniProt A0AV49 B2RMV3 P52732 Q15716 Q5VWX0

Target Cross References - Domain

InterPro IPR001752 (Kinesin_motor_dom.)
IPR019821 (Kinesin_motor_CS.)
IPR025901 (Kinesin-assoc_MT-bd_dom.)
IPR027417 (P-loop_NTPase.)
IPR027640 (Kinesin-like_fam.)
IPR036961 (Kinesin_motor_dom_sf.)
Pfam PF00225 (Kinesin)
PF13931 (Microtub_bind)

Target Cross References - Structure

PDBe 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD More...
CREDO 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2FME 2G1Q 2GM1 2IEH 2PG2 2Q2Y 2Q2Z 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 3CJO 3HQD More...
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