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Target Report Card

Target Name and Classification

Target ID CHEMBL4552
Target Type SINGLE PROTEIN
Preferred Name Peripheral-type benzodiazepine receptor
Synonyms Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral-type benzodiazepine receptor | Translocator protein | Tspo
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Translocator protein SINGLE PROTEIN P16257

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096683 Benzodiazepine receptors; peripheral & central SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031966 (mitochondrial membrane)
GO Molecular Function GO:0005497 (androgen binding)
GO:0005515 (protein binding)
GO:0008503 (benzodiazepine receptor activity)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006694 (steroid biosynthetic process)
GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0006869 (lipid transport)
GO:0007165 (signal transduction)
GO:0007568 (aging)
GO:0008347 (glial cell migration)
GO:0010042 (response to manganese ion)
GO:0010266 (response to vitamin B1)
GO:0010823 (negative regulation of mitochondrion organization)
GO:0010940 (positive regulation of necrotic cell death)
GO:0014012 (peripheral nervous system axon regeneration)
GO:0030325 (adrenal gland development)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0032570 (response to progesterone)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0033574 (response to testosterone)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0048265 (response to pain)
GO:0048266 (behavioral response to pain)
GO:0048678 (response to axon injury)
GO:0050810 (regulation of steroid biosynthetic process)
GO:0051901 (positive regulation of mitochondrial depolarization)
GO:0051928 (positive regulation of calcium ion transport)
GO:0060242 (contact inhibition)
GO:0060252 (positive regulation of glial cell proliferation)
GO:0060253 (negative regulation of glial cell proliferation)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071294 (cellular response to zinc ion)
GO:0071476 (cellular hypotonic response)
GO:0072655 (establishment of protein localization to mitochondrion)
GO:0072656 (maintenance of protein location in mitochondrion)
GO:1903147 (negative regulation of mitophagy)
GO:1903579 (negative regulation of ATP metabolic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)

Target Cross References - Protein

canSAR P16257
Guide to Pharmacology 2879
MICAD NBK23034 (Peripheral-type benzodiazepine receptor)
NBK23087 (Peripheral-type benzodiazepine receptor (PBR))
NBK23156 (Peripheral benzodiazepine receptor, PBR)
NBK23161 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK23277 (Peripheral-type benzodiazepine receptor)
NBK23316 (Peripheral benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK23412 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK23422 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK23484 (Peripheral-type benzodiazepine receptor (PBR, TSPO))
NBK23547 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK23620 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK23694 (Peripheral-type benzodiazepine receptor (PBR))
NBK44809 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK45545 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
NBK45546 (Peripheral-type benzodiazepine receptor (PBR), also known as translocator protein (TSPO))
Reactome R-RNO-196108 (Pregnenolone biosynthesis.)
UniProt P16257

Target Cross References - Domain

InterPro IPR004307 (TspO_MBR.)
IPR030164 (TSPO.)
Pfam PF03073 (TspO_MBR)
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