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Target Report Card

Target Name and Classification

Target ID CHEMBL4521
Preferred Name Cytochrome P450 24A1
Synonyms 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | 24-OHase | CYP24 | CYP24A1 | Cytochrome P450 24A1 | Cytochrome P450-CC24 | Vitamin D(3) 24-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial SINGLE PROTEIN Q07973

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000019186
Ensembl ENSG00000019186
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008403 (25-hydroxycholecalciferol-24-hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0020037 (heme binding)
GO:0030342 (1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001649 (osteoblast differentiation)
GO:0006766 (vitamin metabolic process)
GO:0033280 (response to vitamin D)
GO:0042359 (vitamin D metabolic process)
GO:0042369 (vitamin D catabolic process)
GO:0055114 (oxidation-reduction process)
GO:0070561 (vitamin D receptor signaling pathway)
Wikipedia CYP24A1

Target Cross References - Protein

canSAR Q07973
CGD 1,25(OH)(2)D-24-hydroxylase deficiency
Human Protein Atlas ENSG00000019186
IntAct Q07973
Guide to Pharmacology 1365
Open Targets ENSG00000019186
PharmGKB PA27097
Reactome R-HSA-196791 (Vitamin D (calciferol) metabolism.)
R-HSA-211916 (Vitamins.)
R-HSA-5579010 (Defective CYP24A1 causes Hypercalcemia, infantile (HCAI).)
UniProt Q07973 Q15807 Q32ML3 Q5I2W7

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)