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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4471
Target Type SINGLE PROTEIN
Preferred Name Thrombin
Synonyms Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin | Thrombin heavy chain | Thrombin light chain
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Prothrombin SINGLE PROTEIN P00735

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0070051 (fibrinogen binding)
GO:0070053 (thrombospondin receptor activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006508 (proteolysis)
GO:0006953 (acute-phase response)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0008284 (positive regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0009611 (response to wounding)
GO:0010468 (regulation of gene expression)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0030168 (platelet activation)
GO:0030194 (positive regulation of blood coagulation)
GO:0030307 (positive regulation of cell growth)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0042730 (fibrinolysis)
GO:0045861 (negative regulation of proteolysis)
GO:0048712 (negative regulation of astrocyte differentiation)
GO:0051258 (protein polymerization)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:1900738 (positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)

Target Cross References - Protein

canSAR P00735
IntAct P00735
Reactome R-BTA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-BTA-140875 (Common Pathway of Fibrin Clot Formation.)
R-BTA-159740 (Gamma-carboxylation of protein precursors.)
R-BTA-159763 (Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.)
R-BTA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
R-BTA-202733 (Cell surface interactions at the vascular wall.)
R-BTA-375276 (Peptide ligand-binding receptors.)
R-BTA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-BTA-416476 (G alpha (q) signalling events.)
R-BTA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
R-BTA-76009 (Platelet Aggregation (Plug Formation).)
UniProt P00735 Q3MHK7

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR000294 (GLA_domain.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR003966 (Prothrombin/thrombin.)
IPR009003 (Peptidase_S1_PA.)
IPR013806 (Kringle-like.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018056 (Kringle_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR018992 (Thrombin_light_chain.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00051 (Kringle)
PF00089 (Trypsin)
PF00594 (Gla)
PF09396 (Thrombin_light)

Target Cross References - Structure

PDBe 1A0H 1AVG 1BBR 1ETR 1ETS 1ETT 1HRT 1ID5 1MKW 1MKX 1NL1 1NL2 1TBQ 1TBR 1TOC 1UCY 1UVT 1UVU 1VIT 1YCP 2A1D 2HPP 2ODY 2PF1 More...
CREDO 1A0H 1AVG 1BBR 1ETR 1ETS 1ETT 1HRT 1ID5 1MKW 1MKX 1NL1 1NL2 1TBQ 1TBR 1TOC 1UCY 1UVT 1UVU 1VIT 1YCP 2A1D 2HPP 2ODY 2PF1 More...
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