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Target Report Card

Target Name and Classification

Target ID CHEMBL4454
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase FGR
Synonyms FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Proto-oncogene c-Fgr | SRC2 | Tyrosine-protein kinase Fgr | p55-Fgr | p58-Fgr | p58c-Fgr
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Fgr SINGLE PROTEIN P09769

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363074 SRC PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000000938
Ensembl ENSG00000000938
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005758 (mitochondrial intermembrane space)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016235 (aggresome)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032587 (ruffle membrane)
GO:0034774 (secretory granule lumen)
GO:0042995 (cell projection)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001784 (phosphotyrosine binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0034987 (immunoglobulin receptor binding)
GO:0034988 (Fc-gamma receptor I complex binding)
GO Biological Process GO:0002376 (immune system process)
GO:0002768 (immune response-regulating cell surface receptor signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0008360 (regulation of cell shape)
GO:0009615 (response to virus)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0043312 (neutrophil degranulation)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045087 (innate immune response)
GO:0045088 (regulation of innate immune response)
GO:0045859 (regulation of protein kinase activity)
GO:0046777 (protein autophosphorylation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050764 (regulation of phagocytosis)
GO:0050830 (defense response to Gram-positive bacterium)
Wikipedia FGR_(gene)

Target Cross References - Protein

canSAR P09769
Human Protein Atlas ENSG00000000938
IntAct P09769
Guide to Pharmacology 2024
Open Targets ENSG00000000938
PharmGKB PA28135
Pharos P09769 (Tchem)
Reactome R-HSA-2029481 (FCGR activation.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt D3DPL7 P09769 Q9UIQ3

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035693 (Fgr_SH2.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
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