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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4444
Target Type SINGLE PROTEIN
Preferred Name Vitamin K-dependent protein C
Synonyms Activation peptide | Anticoagulant protein C | Autoprothrombin IIA | Blood coagulation factor XIV | PROC | Vitamin K-dependent protein C heavy chain | Vitamin K-dependent protein C light chain | Vitamin K-dependent protein C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Vitamin K-dependent protein C SINGLE PROTEIN P04070

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115718
Ensembl ENSG00000115718
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005783 (endoplasmic reticulum)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005794 (Golgi apparatus)
GO:0005796 (Golgi lumen)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0001889 (liver development)
GO:0006465 (signal peptide processing)
GO:0006508 (proteolysis)
GO:0006888 (ER to Golgi vesicle-mediated transport)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0030195 (negative regulation of blood coagulation)
GO:0043066 (negative regulation of apoptotic process)
GO:0043687 (post-translational protein modification)
GO:0044267 (cellular protein metabolic process)
GO:0044537 (regulation of circulating fibrinogen levels)
GO:0050728 (negative regulation of inflammatory response)
GO:0050819 (negative regulation of coagulation)
GO:0050900 (leukocyte migration)
GO:1903142 (positive regulation of establishment of endothelial barrier)

Target Cross References - Protein

canSAR P04070
CGD Thrombophilia, hereditary, due to protein C deficiency
Human Protein Atlas ENSG00000115718
IntAct P04070
Guide to Pharmacology 2396
Open Targets ENSG00000115718
PharmGKB PA33799
Reactome R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
R-HSA-140875 (Common Pathway of Fibrin Clot Formation.)
R-HSA-159740 (Gamma-carboxylation of protein precursors.)
R-HSA-159763 (Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.)
R-HSA-159782 (Removal of aminoterminal propeptides from gamma-carboxylated proteins.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-8957275 (Post-translational protein phosphorylation.)
UniProt B4DPQ7 P04070 Q15189 Q15190 Q16001 Q53S74 Q9UC55

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000294 (GLA_domain.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR012224 (Pept_S1A_FX.)
IPR013032 (EGF-like_CS.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018097 (EGF_Ca-bd_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
IPR035972 (GLA-like_dom_SF.)
Pfam PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)

Target Cross References - Structure

PDBe 1AUT 1LQV 3F6U 3JTC 4DT7
CREDO 1AUT 1LQV 3F6U 3JTC 4DT7
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