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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4409
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 10A
Synonyms PDE10A | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 10 > phosphodiesterase 10a

Target Components

Component Description Relationship Accession
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A SINGLE PROTEIN Q9Y233

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545271 PBF-999 Phosphodiesterase 10A inhibitor 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112541
Ensembl ENSG00000112541
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0004112 (cyclic-nucleotide phosphodiesterase activity)
GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0004118 (cGMP-stimulated cyclic-nucleotide phosphodiesterase activity)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0008144 (drug binding)
GO:0016787 (hydrolase activity)
GO:0030552 (cAMP binding)
GO:0030553 (cGMP binding)
GO:0046872 (metal ion binding)
GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
GO Biological Process GO:0006198 (cAMP catabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0008152 (metabolic process)
GO:0010738 (regulation of protein kinase A signaling)
GO:0043949 (regulation of cAMP-mediated signaling)
GO:0046069 (cGMP catabolic process)
Wikipedia PDE10A

Target Cross References - Protein

canSAR Q9Y233
Human Protein Atlas ENSG00000112541
IntAct Q9Y233
Guide to Pharmacology 1310
Open Targets ENSG00000112541
PharmGKB PA33120
Reactome R-HSA-418457 (cGMP effects.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt Q6FHX1 Q9HCP9 Q9NTV4 Q9ULW9 Q9Y233 Q9Y5T1

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003018 (GAF.)
IPR003607 (HD/PDEase_dom.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR029016 (GAF-like_dom_sf.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)
PF01590 (GAF)

Target Cross References - Structure

PDBe 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD More...
CREDO 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD More...
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