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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4400
Target Type SINGLE PROTEIN
Preferred Name Beta-3 adrenergic receptor
Synonyms ADRB3 | B3AR | Beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor
Organism Canis lupus familiaris
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Beta-3 adrenergic receptor SINGLE PROTEIN O02662

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004939 (beta-adrenergic receptor activity)
GO:0015052 (beta3-adrenergic receptor activity)
GO:0042803 (protein homodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0002025 (vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007267 (cell-cell signaling)
GO:0043410 (positive regulation of MAPK cascade)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)

Target Cross References - Protein

canSAR O02662
UniProt O02662 Q9TTT2

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000681 (ADRB3_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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