ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4398
Preferred Name Purinergic receptor P2Y2
Synonyms ATP receptor | P2RU1 | P2RY2 | P2U purinoceptor 1 | P2U receptor 1 | P2U1 | P2Y purinoceptor 2 | P2Y2 | Purinergic receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > purine receptor

Target Components

Component Description Relationship Accession
P2Y purinoceptor 2 SINGLE PROTEIN P41231

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1767407 DENUFOSOL TETRASODIUM Purinergic receptor P2Y2 agonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175591
Ensembl ENSG00000175591
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0038023 (signaling receptor activity)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO Biological Process GO:0006873 (cellular ion homeostasis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
GO:0070257 (positive regulation of mucus secretion)
GO:0097746 (regulation of blood vessel diameter)
Wikipedia P2RY2

Target Cross References - Protein

Human Protein Atlas ENSG00000175591
IntAct P41231
Guide to Pharmacology 324
Open Targets ENSG00000175591
PharmGKB PA32870
Pharos P41231 (Tclin)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-417957 (P2Y receptors.)
R-HSA-5683826 (Surfactant metabolism.)
UniProt B2R9W3 P41231 Q96EM8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000356 (P2Y2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)