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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4391
Target Type SINGLE PROTEIN
Preferred Name Fructose-1,6-bisphosphatase
Synonyms D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBPase 1 | Fbp | Fbp1 | Fructose-1,6-bisphosphatase 1 | Liver FBPase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Fructose-1,6-bisphosphatase 1 SINGLE PROTEIN P19112

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0016208 (AMP binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0042132 (fructose 1,6-bisphosphate 1-phosphatase activity)
GO:0042578 (phosphoric ester hydrolase activity)
GO:0046872 (metal ion binding)
GO:0048029 (monosaccharide binding)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0005986 (sucrose biosynthetic process)
GO:0006000 (fructose metabolic process)
GO:0006002 (fructose 6-phosphate metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006111 (regulation of gluconeogenesis)
GO:0008152 (metabolic process)
GO:0016311 (dephosphorylation)
GO:0030308 (negative regulation of cell growth)
GO:0030388 (fructose 1,6-bisphosphate metabolic process)
GO:0032869 (cellular response to insulin stimulus)
GO:0035690 (cellular response to drug)
GO:0045820 (negative regulation of glycolytic process)
GO:0046580 (negative regulation of Ras protein signal transduction)
GO:0051289 (protein homotetramerization)
GO:0071286 (cellular response to magnesium ion)

Target Cross References - Protein

canSAR P19112
UniProt P19112 Q64594

Target Cross References - Domain

InterPro IPR000146 (FBPase_class-1.)
IPR020548 (Fructose_bisphosphatase_AS.)
IPR028343 (FBPtase.)
IPR033391 (FBPase_N.)
Pfam PF00316 (FBPase)
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