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Target Report Card

Target Name and Classification

Target ID CHEMBL4355
Preferred Name Serine/threonine-protein kinase GAK
Synonyms Cyclin-G-associated kinase | GAK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nak family

Target Components

Component Description Relationship Accession
Cyclin-G-associated kinase SINGLE PROTEIN O14976

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178950
Ensembl ENSG00000178950
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031982 (vesicle)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006898 (receptor-mediated endocytosis)
GO:0007029 (endoplasmic reticulum organization)
GO:0007030 (Golgi organization)
GO:0007049 (cell cycle)
GO:0010977 (negative regulation of neuron projection development)
GO:0016191 (synaptic vesicle uncoating)
GO:0016310 (phosphorylation)
GO:0034067 (protein localization to Golgi apparatus)
GO:0051085 (chaperone mediated protein folding requiring cofactor)
GO:0061024 (membrane organization)
GO:0072318 (clathrin coat disassembly)
GO:0072583 (clathrin-mediated endocytosis)
GO:0072659 (protein localization to plasma membrane)
GO:0090160 (Golgi to lysosome transport)
GO:1905224 (clathrin-coated pit assembly)
Wikipedia GAK_(protein)

Target Cross References - Protein

canSAR O14976
Human Protein Atlas ENSG00000178950
IntAct O14976
Guide to Pharmacology 2027
Open Targets ENSG00000178950
PharmGKB PA28528
Pharos O14976 (Tchem)
Reactome R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt O14976 Q5U4P5 Q9BVY6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001623 (DnaJ_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR014020 (Tensin_C2-dom.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
IPR029023 (Tensin_phosphatase.)
IPR035892 (C2_domain_sf.)
IPR036869 (J_dom_sf.)
Pfam PF00069 (Pkinase)
PF10409 (PTEN_C2)

Target Cross References - Structure

PDBe 4C57 4C58 4C59 4O38 4Y8D
CREDO 4C57 4C58 4C59 4O38 4Y8D