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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4354
Preferred Name Mu opioid receptor
Synonyms M-OR-1 | MOR-1 | Mu-type opioid receptor | OPRM1
Organism Cavia porcellus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > opioid receptor

Target Components

Component Description Relationship Accession
Mu-type opioid receptor SINGLE PROTEIN P97266

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038518 mu/kappa opioid receptor PROTEIN FAMILY
CHEMBL2111465 Opioid receptor (mu and kappa) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0042995 (cell projection)
GO:0043204 (perikaryon)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004985 (opioid receptor activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0038047 (morphine receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0019233 (sensory perception of pain)
GO:0038003 (opioid receptor signaling pathway)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0050769 (positive regulation of neurogenesis)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0061358 (negative regulation of Wnt protein secretion)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070588 (calcium ion transmembrane transport)
GO:0071315 (cellular response to morphine)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)

Target Cross References - Protein

canSAR P97266
UniProt P97266

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001418 (Opioid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)