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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4338
Preferred Name Purine nucleoside phosphorylase
Synonyms Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNP | Purine nucleoside phosphorylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Purine nucleoside phosphorylase SINGLE PROTEIN P00491

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL550755 FORODESINE HYDROCHLORIDE Purine nucleoside phosphorylase inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198805
Ensembl ENSG00000198805
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0034774 (secretory granule lumen)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0001882 (nucleoside binding)
GO:0002060 (purine nucleobase binding)
GO:0003824 (catalytic activity)
GO:0004731 (purine-nucleoside phosphorylase activity)
GO:0008144 (drug binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0016763 (transferase activity, transferring pentosyl groups)
GO:0042301 (phosphate ion binding)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006148 (inosine catabolic process)
GO:0006195 (purine nucleotide catabolic process)
GO:0006738 (nicotinamide riboside catabolic process)
GO:0006955 (immune response)
GO:0009116 (nucleoside metabolic process)
GO:0034356 (NAD biosynthesis via nicotinamide riboside salvage pathway)
GO:0034418 (urate biosynthetic process)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042278 (purine nucleoside metabolic process)
GO:0042493 (response to drug)
GO:0043101 (purine-containing compound salvage)
GO:0043312 (neutrophil degranulation)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0070970 (interleukin-2 secretion)
Wikipedia Purine_nucleoside_phosphorylase

Target Cross References - Protein

canSAR P00491
CGD Purine nucleoside phosphorylase deficiency
Human Protein Atlas ENSG00000198805
IntAct P00491
Guide to Pharmacology 2841
Open Targets ENSG00000198805
PharmGKB PA31694
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-74217 (Purine salvage.)
R-HSA-74259 (Purine catabolism.)
UniProt B2R8S5 D3DS00 P00491 Q15160 Q5PZ03

Target Cross References - Domain

InterPro IPR000845 (Nucleoside_phosphorylase_d.)
IPR011268 (Purine_phosphorylase.)
IPR011270 (Pur_Nuc_Pase_Ino/Guo-sp.)
IPR018099 (Purine_phosphorylase-2_CS.)
IPR035994 (Nucleoside_phosphorylase_sf.)
Pfam PF01048 (PNP_UDP_1)

Target Cross References - Structure

PDBe 1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V More...
CREDO 1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V More...