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Target Report Card

Target Name and Classification

Target ID CHEMBL4336
Preferred Name Prostanoid EP3 receptor
Synonyms PGE receptor EP3 subtype | PGE2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor | Ptger3 | Ptgerep3
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > prostanoid receptor

Target Components

Component Description Relationship Accession
Prostaglandin E2 receptor EP3 subtype SINGLE PROTEIN P30557

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031526 (brush border membrane)
GO:0031965 (nuclear membrane)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:1990769 (proximal neuron projection)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004955 (prostaglandin receptor activity)
GO:0004957 (prostaglandin E receptor activity)
GO:0005515 (protein binding)
GO Biological Process GO:0001660 (fever generation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0010628 (positive regulation of gene expression)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0010840 (regulation of circadian sleep/wake cycle, wakefulness)
GO:0014061 (regulation of norepinephrine secretion)
GO:0014827 (intestine smooth muscle contraction)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0015701 (bicarbonate transport)
GO:0031622 (positive regulation of fever generation)
GO:0031623 (receptor internalization)
GO:0032496 (response to lipopolysaccharide)
GO:0035810 (positive regulation of urine volume)
GO:0043950 (positive regulation of cAMP-mediated signaling)
GO:0045907 (positive regulation of vasoconstriction)
GO:0046010 (positive regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0046676 (negative regulation of insulin secretion)
GO:0060455 (negative regulation of gastric acid secretion)
GO:0090331 (negative regulation of platelet aggregation)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:1901380 (negative regulation of potassium ion transmembrane transport)
GO:1903170 (negative regulation of calcium ion transmembrane transport)
GO:1903524 (positive regulation of blood circulation)
GO:1903640 (negative regulation of gastrin-induced gastric acid secretion)
GO:1904320 (positive regulation of smooth muscle contraction involved in micturition)
GO:1904322 (cellular response to forskolin)
GO:1904325 (positive regulation of inhibitory G-protein coupled receptor phosphorylation)
GO:1904326 (negative regulation of circadian sleep/wake cycle, wakefulness)
GO:1904330 (positive regulation of myofibroblast contraction)
GO:1904343 (positive regulation of colon smooth muscle contraction)
GO:1904346 (positive regulation of gastric mucosal blood circulation)
GO:1990767 (prostaglandin receptor internalization)
GO:2000391 (positive regulation of neutrophil extravasation)
GO:2000978 (negative regulation of forebrain neuron differentiation)

Target Cross References - Protein

canSAR P30557
Guide to Pharmacology 342
UniProt P30557

Target Cross References - Domain

InterPro IPR000154 (EP3_rcpt_3.)
IPR000265 (Prostglndn_EP3_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR001244 (Prostglndn_DP_rcpt.)
IPR008365 (Prostanoid_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)