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Target Report Card

Target Name and Classification

Target ID CHEMBL4333
Preferred Name Sphingosine 1-phosphate receptor Edg-1
Synonyms CD_antigen=CD363 | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor 1 | S1P receptor Edg-1 | S1P1 | S1PR1 | Sphingosine 1-phosphate receptor 1 | Sphingosine 1-phosphate receptor Edg-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > edg receptor

Target Components

Component Description Relationship Accession
Sphingosine 1-phosphate receptor 1 SINGLE PROTEIN P21453

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363041 Sphingosine 1-phosphate receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2336071 SIPONIMOD Sphingosine 1-phosphate receptor Edg-1 agonist 3 PubMed PubMed
CHEMBL1096146 PONESIMOD Sphingosine 1-phosphate receptor Edg-1 agonist 2 PubMed PubMed
CHEMBL3358920 ETRASIMOD Sphingosine 1-phosphate receptor Edg-1 agonist 2 Other PubMed
CHEMBL3545101 KRP203 Sphingosine 1-phosphate receptor Edg-1 agonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000170989
Ensembl ENSG00000170989
GO Cellular Component GO:0005654 (nucleoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045121 (membrane raft)
GO Molecular Function GO:0001664 (G-protein coupled receptor binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0038036 (sphingosine-1-phosphate receptor activity)
GO:0046625 (sphingolipid binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001955 (blood vessel maturation)
GO:0003245 (cardiac muscle tissue growth involved in heart morphogenesis)
GO:0003376 (sphingosine-1-phosphate signaling pathway)
GO:0006935 (chemotaxis)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007420 (brain development)
GO:0008284 (positive regulation of cell proliferation)
GO:0016477 (cell migration)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019226 (transmission of nerve impulse)
GO:0030032 (lamellipodium assembly)
GO:0030155 (regulation of cell adhesion)
GO:0030182 (neuron differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030500 (regulation of bone mineralization)
GO:0030595 (leukocyte chemotaxis)
GO:0031532 (actin cytoskeleton reorganization)
GO:0043547 (positive regulation of GTPase activity)
GO:0045124 (regulation of bone resorption)
GO:0045446 (endothelial cell differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051497 (negative regulation of stress fiber assembly)
GO:0061384 (heart trabecula morphogenesis)
GO:0072678 (T cell migration)
Wikipedia S1PR1

Target Cross References - Protein

canSAR P21453
Human Protein Atlas ENSG00000170989
IntAct P21453
Guide to Pharmacology 275
Open Targets ENSG00000170989
PharmGKB PA162402344
Pharos P21453 (Tclin)
Reactome R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-419408 (Lysosphingolipid and LPA receptors.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt D3DT66 P21453 Q9BYY4 Q9NYN8

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000987 (EDG1_rcpt.)
IPR004061 (S1P_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 3V2W 3V2Y