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Target Report Card

Target Name and Classification

Target ID CHEMBL4315
Target Type SINGLE PROTEIN
Preferred Name Purinergic receptor P2Y1
Synonyms ATP receptor | P2RY1 | P2Y purinoceptor 1 | P2Y1 | Purinergic receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > purine receptor

Target Components

Component Description Relationship Accession
P2Y purinoceptor 1 SINGLE PROTEIN P47900

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169860
Ensembl ENSG00000169860
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0030425 (dendrite)
GO:0044297 (cell body)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0031686 (A1 adenosine receptor binding)
GO:0038023 (signaling receptor activity)
GO:0043531 (ADP binding)
GO:0045028 (G-protein coupled purinergic nucleotide receptor activity)
GO:0045031 (ATP-activated adenosine receptor activity)
GO:0045032 (ADP-activated adenosine receptor activity)
GO:0046982 (protein heterodimerization activity)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0001973 (adenosine receptor signaling pathway)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007568 (aging)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0008347 (glial cell migration)
GO:0009612 (response to mechanical stimulus)
GO:0010469 (regulation of receptor activity)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0019233 (sensory perception of pain)
GO:0023019 (signal transduction involved in regulation of gene expression)
GO:0030168 (platelet activation)
GO:0032962 (positive regulation of inositol trisphosphate biosynthetic process)
GO:0035589 (G-protein coupled purinergic nucleotide receptor signaling pathway)
GO:0042060 (wound healing)
GO:0042755 (eating behavior)
GO:0043270 (positive regulation of ion transport)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046887 (positive regulation of hormone secretion)
GO:0051100 (negative regulation of binding)
GO:0060406 (positive regulation of penile erection)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070848 (response to growth factor)
GO:0071407 (cellular response to organic cyclic compound)
GO:0072659 (protein localization to plasma membrane)
GO:0090075 (relaxation of muscle)
GO:0097746 (regulation of blood vessel diameter)
Wikipedia P2RY1

Target Cross References - Protein

canSAR P47900
Human Protein Atlas ENSG00000169860
IntAct P47900
Guide to Pharmacology 323
Open Targets ENSG00000169860
PharmGKB PA32868
Pharos P47900 (Tchem)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-417957 (P2Y receptors.)
R-HSA-418592 (ADP signalling through P2Y purinoceptor 1.)
UniProt P47900

Target Cross References - Domain

InterPro IPR000142 (P2Y1_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4XNV 4XNW
CREDO 4XNV 4XNW
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