ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL4302
Preferred Name P-glycoprotein 1
Synonyms ABCB1 | ATP-binding cassette sub-family B member 1 | CD_antigen=CD243 | MDR1 | Multidrug resistance protein 1 | P-glycoprotein 1 | PGY1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcb subfamily

Target Components

Component Description Relationship Accession
Multidrug resistance protein 1 SINGLE PROTEIN P08183

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430875 Multidrug resistance protein 1/Multidrug resistance associated protein 1 SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL348475 TARIQUIDAR P-glycoprotein 1 inhibitor 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000085563
Ensembl ENSG00000085563
GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005215 (transporter activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0016787 (hydrolase activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO:0090554 (phosphatidylcholine-translocating ATPase activity)
GO:0090555 (phosphatidylethanolamine-translocating ATPase activity)
GO:0099038 (ceramide-translocating ATPase activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006855 (drug transmembrane transport)
GO:0042493 (response to drug)
GO:0042908 (xenobiotic transport)
GO:0045332 (phospholipid translocation)
GO:0047484 (regulation of response to osmotic stress)
GO:0055085 (transmembrane transport)
GO:0072089 (stem cell proliferation)
GO:0099040 (ceramide translocation)
GO:1901529 (positive regulation of anion channel activity)
GO:2001225 (regulation of chloride transport)
Wikipedia P-glycoprotein

Target Cross References - Protein

canSAR P08183
CGD Colchicine metabolism, association with
Human Protein Atlas ENSG00000085563
IntAct P08183
MICAD NBK23098 (P-glycoprotein, MDR-1, mitochondria)
NBK23561 (P-glycoprotein multidrug transporter, MDR-1)
NBK23721 (P-glycoprotein (P-gp) multidrug transporter, MDR-1)
Open Targets ENSG00000085563
PharmGKB PA267
Reactome R-HSA-2161517 (Abacavir transmembrane transport.)
R-HSA-382556 (ABC-family proteins mediated transport.)
UniProt A8K294 B5AK60 P08183 Q12755 Q14812

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR011527 (ABC1_TM_dom.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR030258 (MDR1.)
IPR036640 (ABC1_TM_sf.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)