ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL4261
Target Type SINGLE PROTEIN
Preferred Name Hypoxia-inducible factor 1 alpha
Synonyms ARNT-interacting protein | Basic-helix-loop-helix-PAS protein MOP1 | Class E basic helix-loop-helix protein 78 | HIF-1-alpha | HIF1-alpha | HIF1A | Hypoxia-inducible factor 1-alpha | MOP1 | Member of PAS protein 1 | PAS domain-containing protein 8 | PASD8 | Synonyms=BHLHE78 | bHLHe78
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor

Target Components

Component Description Relationship Accession
Hypoxia-inducible factor 1-alpha SINGLE PROTEIN Q16665

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221345 Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha PROTEIN FAMILY
CHEMBL3885588 Histone acetyltransferase p300/Hypoxia-inducible factor 1-alpha PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100644
Ensembl ENSG00000100644
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016604 (nuclear body)
GO:0016607 (nuclear speck)
GO:0031514 (motile cilium)
GO:0032991 (macromolecular complex)
GO:0090575 (RNA polymerase II transcription factor complex)
GO:1904115 (axon cytoplasm)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0000989 (transcription factor activity, transcription factor binding)
GO:0001076 (transcription factor activity, RNA polymerase II transcription factor binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0002039 (p53 binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0035035 (histone acetyltransferase binding)
GO:0035257 (nuclear hormone receptor binding)
GO:0042826 (histone deacetylase binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO:0051879 (Hsp90 protein binding)
GO:0070888 (E-box binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001568 (blood vessel development)
GO:0001666 (response to hypoxia)
GO:0001755 (neural crest cell migration)
GO:0001837 (epithelial to mesenchymal transition)
GO:0001892 (embryonic placenta development)
GO:0001922 (B-1 B cell homeostasis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0001944 (vasculature development)
GO:0001947 (heart looping)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0002248 (connective tissue replacement involved in inflammatory response wound healing)
GO:0003151 (outflow tract morphogenesis)
GO:0003208 (cardiac ventricle morphogenesis)
GO:0006089 (lactate metabolic process)
GO:0006110 (regulation of glycolytic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006879 (cellular iron ion homeostasis)
GO:0007165 (signal transduction)
GO:0007595 (lactation)
GO:0008542 (visual learning)
GO:0010039 (response to iron ion)
GO:0010468 (regulation of gene expression)
GO:0010508 (positive regulation of autophagy)
GO:0010573 (vascular endothelial growth factor production)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0014850 (response to muscle activity)
GO:0016239 (positive regulation of macroautophagy)
GO:0016567 (protein ubiquitination)
GO:0016579 (protein deubiquitination)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019896 (axonal transport of mitochondrion)
GO:0021502 (neural fold elevation formation)
GO:0021987 (cerebral cortex development)
GO:0030154 (cell differentiation)
GO:0030279 (negative regulation of ossification)
GO:0030502 (negative regulation of bone mineralization)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0032007 (negative regulation of TOR signaling)
GO:0032364 (oxygen homeostasis)
GO:0032722 (positive regulation of chemokine production)
GO:0032909 (regulation of transforming growth factor beta2 production)
GO:0032963 (collagen metabolic process)
GO:0035162 (embryonic hemopoiesis)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0042127 (regulation of cell proliferation)
GO:0042541 (hemoglobin biosynthetic process)
GO:0042593 (glucose homeostasis)
GO:0042789 (mRNA transcription from RNA polymerase II promoter)
GO:0043066 (negative regulation of apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0043619 (regulation of transcription from RNA polymerase II promoter in response to oxidative stress)
GO:0043687 (post-translational protein modification)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045821 (positive regulation of glycolytic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045926 (negative regulation of growth)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046716 (muscle cell cellular homeostasis)
GO:0046886 (positive regulation of hormone biosynthetic process)
GO:0048514 (blood vessel morphogenesis)
GO:0048546 (digestive tract morphogenesis)
GO:0048593 (camera-type eye morphogenesis)
GO:0050790 (regulation of catalytic activity)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051216 (cartilage development)
GO:0051541 (elastin metabolic process)
GO:0060574 (intestinal epithelial cell maturation)
GO:0061030 (epithelial cell differentiation involved in mammary gland alveolus development)
GO:0061072 (iris morphogenesis)
GO:0061298 (retina vasculature development in camera-type eye)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0061419 (positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0070101 (positive regulation of chemokine-mediated signaling pathway)
GO:0070243 (regulation of thymocyte apoptotic process)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0071347 (cellular response to interleukin-1)
GO:0071456 (cellular response to hypoxia)
GO:0071542 (dopaminergic neuron differentiation)
GO:0097411 (hypoxia-inducible factor-1alpha signaling pathway)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1903377 (negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)
GO:1903599 (positive regulation of mitophagy)
GO:1903715 (regulation of aerobic respiration)
GO:2000378 (negative regulation of reactive oxygen species metabolic process)
GO:2001054 (negative regulation of mesenchymal cell apoptotic process)
Wikipedia HIF1A

Target Cross References - Protein

canSAR Q16665
Human Protein Atlas ENSG00000100644
IntAct Q16665
Open Targets ENSG00000100644
PharmGKB PA29283
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1234162 (Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha.)
R-HSA-1234176 (Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-400253 (Circadian Clock.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-8849473 (PTK6 Expression.)
R-HSA-8857538 (PTK6 promotes HIF1A stabilization.)
R-HSA-8951664 (Neddylation.)
TIMBAL HIF-1a
UniProt C0LZJ3 Q16665 Q53XP6 Q96PT9 Q9UPB1

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR001321 (HIF-1_alpha.)
IPR001610 (PAC.)
IPR011598 (bHLH_dom.)
IPR013655 (PAS_fold_3.)
IPR013767 (PAS_fold.)
IPR014887 (HIF-1_TAD_C.)
IPR021537 (HIF_alpha_subunit.)
IPR035965 (PAS-like_dom_sf.)
IPR036638 (HLH_DNA-bd_sf.)
Pfam PF00989 (PAS)
PF08447 (PAS_3)
PF08778 (HIF-1a_CTAD)
PF11413 (HIF-1)

Target Cross References - Structure

PDBe 1H2K 1H2L 1H2M 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS
CREDO 1H2K 1H2L 1H2M 1LM8 1LQB 2ILM 3HQR 3HQU 4AJY 4H6J 5JWP 5L9B 5L9V 5LA9 5LAS
spacer
spacer