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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4225
Target Type SINGLE PROTEIN
Preferred Name Dual specificity protein kinase CLK2
Synonyms CDC-like kinase 2 | CLK2 | Dual specificity protein kinase CLK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase clk family

Target Components

Component Description Relationship Accession
Dual specificity protein kinase CLK2 SINGLE PROTEIN P49760

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176444 ENSG00000261893
Ensembl ENSG00000176444 ENSG00000261893
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0016607 (nuclear speck)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0010033 (response to organic substance)
GO:0010212 (response to ionizing radiation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0032526 (response to retinoic acid)
GO:0043484 (regulation of RNA splicing)
GO:0045721 (negative regulation of gluconeogenesis)
GO:0046777 (protein autophosphorylation)
Wikipedia CLK2

Target Cross References - Protein

canSAR P49760
Human Protein Atlas ENSG00000176444 ENSG00000261893
IntAct P49760
Guide to Pharmacology 1991
Open Targets ENSG00000176444 ENSG00000261893
PharmGKB PA26595
Pharos P49760 (Tchem)
UniProt B1AVS9 B5MBX6 P49760 Q96CQ0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3NR9
CREDO 3NR9
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