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Target Report Card

Target Name and Classification

Target ID CHEMBL4159
Preferred Name Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
Synonyms 17-beta-HSD 10 | 17-beta-hydroxysteroid dehydrogenase 10 | 2-methyl-3-hydroxybutyryl-CoA dehydrogenase | 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | 3-hydroxyacyl-CoA dehydrogenase type II | 3-hydroxyacyl-CoA dehydrogenase type-2 | ERAB | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | HADH2 | HSD17B10 | MHBD | MRPP2 | Mitochondrial RNase P protein 2 | Mitochondrial ribonuclease P protein 2 | SCHAD | SDR5C1 | Short chain dehydrogenase/reductase family 5C member 1 | Short-chain type dehydrogenase/reductase XH98G2 | Type II HADH | XH98G2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
3-hydroxyacyl-CoA dehydrogenase type-2 SINGLE PROTEIN Q99714

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000072506
Ensembl ENSG00000072506
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005886 (plasma membrane)
GO:0030678 (mitochondrial ribonuclease P complex)
GO Molecular Function GO:0000049 (tRNA binding)
GO:0003723 (RNA binding)
GO:0003857 (3-hydroxyacyl-CoA dehydrogenase activity)
GO:0005515 (protein binding)
GO:0008709 (cholate 7-alpha-dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO:0030283 (testosterone dehydrogenase [NAD(P)] activity)
GO:0047015 (3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0007005 (mitochondrion organization)
GO:0008033 (tRNA processing)
GO:0009083 (branched-chain amino acid catabolic process)
GO:0051289 (protein homotetramerization)
GO:0055114 (oxidation-reduction process)
GO:0070901 (mitochondrial tRNA methylation)
GO:0090646 (mitochondrial tRNA processing)
GO:0097745 (mitochondrial tRNA 5'-end processing)
GO:1990180 (mitochondrial tRNA 3'-end processing)
Wikipedia HSD17B10

Target Cross References - Protein

canSAR Q99714
CGD 17-beta-hydroxysteroid dehydrogenase X deficiency; Mental retardation, X-linked syndromic 10
Human Protein Atlas ENSG00000072506
IntAct Q99714
Open Targets ENSG00000072506
PharmGKB PA162391638
Reactome R-HSA-6785470 (tRNA processing in the mitochondrion.)
R-HSA-6787450 (tRNA modification in the mitochondrion.)
R-HSA-70895 (Branched-chain amino acid catabolism.)
R-HSA-8868766 (rRNA processing in the mitochondrion.)
UniProt Q5H927 Q6IBS9 Q8TCV9 Q96HD5 Q99714

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR020904 (Sc_DH/Rdtase_CS.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00106 (adh_short)

Target Cross References - Structure

PDBe 1SO8 1U7T 2O23
CREDO 1SO8 1U7T 2O23