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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4143
Target Type SINGLE PROTEIN
Preferred Name Calpain 2
Synonyms CANP 2 | CAPN2 | Calcium-activated neutral proteinase 2 | Calpain M-type | Calpain-2 catalytic subunit | Calpain-2 large subunit | M-calpain | Millimolar-calpain
Organism Sus scrofa
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c2 family

Target Components

Component Description Relationship Accession
Calpain-2 catalytic subunit SINGLE PROTEIN P43367

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030425 (dendrite)
GO Molecular Function GO:0004198 (calcium-dependent cysteine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0051493 (regulation of cytoskeleton organization)
GO:0071230 (cellular response to amino acid stimulus)

Target Cross References - Protein

canSAR P43367
UniProt P43367

Target Cross References - Domain

InterPro IPR002048 (EF_hand_dom.)
IPR011992 (EF-hand-dom_pair.)
IPR018247 (EF_Hand_1_Ca_BS.)
IPR022682 (Calpain_domain_III.)
IPR022683 (Calpain_III.)
IPR029539 (CAPN2.)
IPR033883 (C2_III.)
IPR036213 (Calpain_III_sf.)
Pfam PF01067 (Calpain_III)
PF13833 (EF-hand_8)
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