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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4140
Target Type SINGLE PROTEIN
Preferred Name Epoxide hydratase
Synonyms Bifunctional epoxide hydrolase 2 | CEH | Cytosolic epoxide hydrolase 2 | Eph2 | Ephx2 | Epoxide hydratase | Lipid-phosphate phosphatase | SEH | Soluble epoxide hydrolase
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s33 family

Target Components

Component Description Relationship Accession
Bifunctional epoxide hydrolase 2 SINGLE PROTEIN P34914

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005777 (peroxisome)
GO:0005829 (cytosol)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003824 (catalytic activity)
GO:0004301 (epoxide hydrolase activity)
GO:0005102 (receptor binding)
GO:0015643 (toxic substance binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0033885 (10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity)
GO:0042577 (lipid phosphatase activity)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002539 (prostaglandin production involved in inflammatory response)
GO:0006629 (lipid metabolic process)
GO:0006954 (inflammatory response)
GO:0008152 (metabolic process)
GO:0009636 (response to toxic substance)
GO:0010628 (positive regulation of gene expression)
GO:0016311 (dephosphorylation)
GO:0019233 (sensory perception of pain)
GO:0019439 (aromatic compound catabolic process)
GO:0042632 (cholesterol homeostasis)
GO:0043651 (linoleic acid metabolic process)
GO:0045777 (positive regulation of blood pressure)
GO:0046272 (stilbene catabolic process)
GO:0046839 (phospholipid dephosphorylation)
GO:0090181 (regulation of cholesterol metabolic process)
GO:0097176 (epoxide metabolic process)

Target Cross References - Protein

canSAR P34914
IntAct P34914
Reactome R-MMU-2142670 (Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).)
UniProt P34914 Q8CGV0

Target Cross References - Domain

InterPro IPR000073 (AB_hydrolase_1.)
IPR000639 (Epox_hydrolase-like.)
IPR006439 (HAD-SF_hydro_IA.)
IPR023198 (PGP_dom2.)
IPR023214 (HAD_sf.)
IPR029058 (AB_hydrolase.)
IPR036412 (HAD-like_sf.)
Pfam PF00561 (Abhydrolase_1)

Target Cross References - Structure

PDBe 1CQZ 1CR6 1EK1 1EK2
CREDO 1CQZ 1CR6 1EK1 1EK2
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