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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4093
Target Type SINGLE PROTEIN
Preferred Name LXR-beta
Synonyms LXRB | Liver X receptor beta | NER | NR1H2 | Nuclear receptor NER | Nuclear receptor subfamily 1 group H member 2 | Oxysterols receptor LXR-beta | UNR | Ubiquitously-expressed nuclear receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group h > nuclear hormone receptor subfamily 1 group h member 3

Target Components

Component Description Relationship Accession
Oxysterols receptor LXR-beta SINGLE PROTEIN P55055

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430878 Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-beta PROTEIN COMPLEX
CHEMBL3706564 Liver X receptor PROTEIN FAMILY
CHEMBL3706565 Liver X receptor (LXR alpha AND LXR beta) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL272621 HYODEOXYCHOLIC_ACID LXR-beta agonist 1 PubMed PubMed
CHEMBL456237 LXR-623 LXR-beta agonist 1 PubMed PubMed
CHEMBL3545047 BMS-852927 LXR-beta modulator 1 PubMed
CHEMBL3545238 CS-8080 LXR-beta agonist 1 PubMed
CHEMBL3545418 BMS-779788 LXR-beta agonist 1 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131408
Ensembl ENSG00000131408
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001077 (transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001133 (RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0034191 (apolipoprotein A-I receptor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046965 (retinoid X receptor binding)
GO:0051117 (ATPase binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010745 (negative regulation of macrophage derived foam cell differentiation)
GO:0010867 (positive regulation of triglyceride biosynthetic process)
GO:0010875 (positive regulation of cholesterol efflux)
GO:0010884 (positive regulation of lipid storage)
GO:0010887 (negative regulation of cholesterol storage)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032369 (negative regulation of lipid transport)
GO:0032376 (positive regulation of cholesterol transport)
GO:0042632 (cholesterol homeostasis)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0044255 (cellular lipid metabolic process)
GO:0045723 (positive regulation of fatty acid biosynthetic process)
GO:0045861 (negative regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0048550 (negative regulation of pinocytosis)
GO:0051006 (positive regulation of lipoprotein lipase activity)
GO:0055088 (lipid homeostasis)
GO:0060336 (negative regulation of interferon-gamma-mediated signaling pathway)
GO:0090108 (positive regulation of high-density lipoprotein particle assembly)
GO:0090187 (positive regulation of pancreatic juice secretion)
GO:0090340 (positive regulation of secretion of lysosomal enzymes)
Wikipedia Liver_X_receptor_beta

Target Cross References - Protein

Human Protein Atlas ENSG00000131408
IntAct P55055
Guide to Pharmacology 601
Open Targets ENSG00000131408
PharmGKB PA31750
Pharos P55055 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
R-HSA-8866427 (VLDLR internalisation and degradation.)
UniProt A8K490 B4DNM6 E7EWA6 P55055 Q12970 Q5I0Y1

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR023257 (Liver_X_rcpt.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ
CREDO 1P8D 1PQ6 1PQ9 1PQC 1UPV 1UPW 3KFC 3L0E 4DK7 4DK8 4NQA 4RAK 5HJP 5I4V 5JY3 5KYA 5KYJ
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