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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4072
Target Type SINGLE PROTEIN
Preferred Name Cathepsin B
Synonyms APP secretase | APPS | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B | Cathepsin B1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c1a family

Target Components

Component Description Relationship Accession
Cathepsin B SINGLE PROTEIN P07858

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111396 Cathepsin (B and K) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164733
Ensembl ENSG00000164733
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005730 (nucleolus)
GO:0005764 (lysosome)
GO:0036021 (endolysosome lumen)
GO:0042470 (melanosome)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0005518 (collagen binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0043394 (proteoglycan binding)
GO Biological Process GO:0002224 (toll-like receptor signaling pathway)
GO:0006508 (proteolysis)
GO:0030574 (collagen catabolic process)
GO:0030855 (epithelial cell differentiation)
GO:0042981 (regulation of apoptotic process)
GO:0043312 (neutrophil degranulation)
GO:0046697 (decidualization)
GO:0046718 (viral entry into host cell)
GO:0050790 (regulation of catalytic activity)
GO:0051603 (proteolysis involved in cellular protein catabolic process)
GO:0097067 (cellular response to thyroid hormone stimulus)
Wikipedia Cathepsin_B

Target Cross References - Protein

canSAR P07858
Human Protein Atlas ENSG00000164733
IntAct P07858
Guide to Pharmacology 2343
Open Targets ENSG00000164733
PharmGKB PA27027
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt B3KQR5 B3KRR5 P07858 Q503A6 Q96D87

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR000668 (Peptidase_C1A_C.)
IPR012599 (Propeptide_C1A.)
IPR013128 (Peptidase_C1A.)
IPR025660 (Pept_his_AS.)
IPR025661 (Pept_asp_AS.)
Pfam PF00112 (Peptidase_C1)
PF08127 (Propeptide_C1)

Target Cross References - Structure

PDBe 1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2
CREDO 1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2
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