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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4047
Target Type SINGLE PROTEIN
Preferred Name Retinoid X receptor beta
Synonyms MHC class I regulatory element-binding protein H-2RIIBP | Nr2b2 | Nuclear receptor subfamily 2 group B member 2 | Retinoic acid receptor RXR-beta | Retinoid X receptor beta | Rxrb
Organism Mus musculus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group b > nuclear hormone receptor subfamily 2 group b member 2

Target Components

Component Description Relationship Accession
Retinoic acid receptor RXR-beta SINGLE PROTEIN P28704

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000980 (RNA polymerase II distal enhancer sequence-specific DNA binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004886 (9-cis retinoic acid receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0030375 (thyroid hormone receptor coactivator activity)
GO:0042803 (protein homodimerization activity)
GO:0042809 (vitamin D receptor binding)
GO:0042974 (retinoic acid receptor binding)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0046966 (thyroid hormone receptor binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0001893 (maternal placenta development)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0031641 (regulation of myelination)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048384 (retinoic acid receptor signaling pathway)
GO:0055012 (ventricular cardiac muscle cell differentiation)
GO:0060038 (cardiac muscle cell proliferation)
GO:0071300 (cellular response to retinoic acid)

Target Cross References - Protein

canSAR P28704
IntAct P28704
Guide to Pharmacology 611
Reactome R-MMU-383280 (Nuclear Receptor transcription pathway.)
R-MMU-5362517 (Signaling by Retinoic Acid.)
UniProt P28704 P33243

Target Cross References - Domain

InterPro IPR000003 (Retinoid-X_rcpt/HNF4.)
IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)
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