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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4028
Target Type SINGLE PROTEIN
Preferred Name Thromboxane-A synthase
Synonyms Cyp5 | Cyp5a1 | Cytochrome P450 5A1 | TXA synthase | TXS | Tbxas1 | Thromboxane-A synthase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 5 > cytochrome p450 family 5a > cytochrome p450 5a1

Target Components

Component Description Relationship Accession
Thromboxane-A synthase SINGLE PROTEIN P49430

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005575 (cellular_component)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0003674 (molecular_function)
GO:0004497 (monooxygenase activity)
GO:0004796 (thromboxane-A synthase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016853 (isomerase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0030644 (cellular chloride ion homeostasis)
GO:0045471 (response to ethanol)
GO:0045907 (positive regulation of vasoconstriction)
GO:0055114 (oxidation-reduction process)
GO:0070542 (response to fatty acid)

Target Cross References - Protein

canSAR P49430
Reactome R-RNO-211979 (Eicosanoids.)
R-RNO-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt P49430

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)
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