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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL4016
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic, AMPA 2
Synonyms AMPA-selective glutamate receptor 2 | GLUR2 | GRIA2 | GluA2 | GluR-2 | GluR-B | GluR-K2 | Glutamate receptor 2 | Glutamate receptor ionotropic, AMPA 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > ampa receptor

Target Components

Component Description Relationship Accession
Glutamate receptor 2 SINGLE PROTEIN P42262

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883294 Glutamate receptor AMPA 1/2 PROTEIN COMPLEX
CHEMBL2096670 Glutamate receptor ionotropic AMPA PROTEIN COMPLEX GROUP
CHEMBL3883291 Glutamate receptor AMPA 2/3 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120251
Ensembl ENSG00000120251
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0030666 (endocytic vesicle membrane)
GO:0032281 (AMPA glutamate receptor complex)
GO:0043197 (dendritic spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0060076 (excitatory synapse)
GO:0098794 (postsynapse)
GO:0098843 (postsynaptic endocytic zone)
GO:0106003 (amyloid-beta complex)
GO Molecular Function GO:0001540 (beta-amyloid binding)
GO:0004970 (ionotropic glutamate receptor activity)
GO:0004971 (AMPA glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005231 (excitatory extracellular ligand-gated ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0006811 (ion transport)
GO:0007165 (signal transduction)
GO:0007268 (chemical synaptic transmission)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0035249 (synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
Wikipedia GRIA2

Target Cross References - Protein

canSAR P42262
Human Protein Atlas ENSG00000120251
IntAct P42262
Guide to Pharmacology 445
Open Targets ENSG00000120251
PharmGKB PA28967
Pharos P42262 (Tclin)
Reactome R-HSA-399710 (Activation of AMPA receptors.)
R-HSA-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
UniProt A8MT92 I6L997 P42262 Q96FP6

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG
CREDO 2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG
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