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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3998
Target Type SINGLE PROTEIN
Preferred Name Dopamine D2 receptor
Synonyms D(2) dopamine receptor | DRD2 | Dopamine D2 receptor
Organism Bos taurus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(2) dopamine receptor SINGLE PROTEIN P20288

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096970 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030672 (synaptic vesicle membrane)
GO Molecular Function GO:0001591 (dopamine neurotransmitter receptor activity, coupled via Gi/Go)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0035240 (dopamine binding)
GO Biological Process GO:0001963 (synaptic transmission, dopaminergic)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007195 (adenylate cyclase-inhibiting dopamine receptor signaling pathway)
GO:0009636 (response to toxic substance)
GO:0014059 (regulation of dopamine secretion)
GO:0042493 (response to drug)
GO:0043266 (regulation of potassium ion transport)
GO:0048148 (behavioral response to cocaine)
GO:0048149 (behavioral response to ethanol)
GO:0051481 (negative regulation of cytosolic calcium ion concentration)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
GO:1902721 (negative regulation of prolactin secretion)
GO:1903488 (negative regulation of lactation)
GO:1903521 (positive regulation of mammary gland involution)

Target Cross References - Protein

canSAR P20288
UniProt P20288

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001922 (Dopamine_D2_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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