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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3991
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor VII
Synonyms Coagulation factor VII | F7 | Factor VII heavy chain | Factor VII light chain | INN=Eptacog alfa | Proconvertin | SPCA | Serum prothrombin conversion accelerator
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Coagulation factor VII SINGLE PROTEIN P08709

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111477 Thrombin and coagulation factor VII SELECTIVITY GROUP
CHEMBL2111412 Coagulation factor VII and X SELECTIVITY GROUP
CHEMBL2095194 Coagulation factor VII/tissue factor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000057593
Ensembl ENSG00000057593
GO Cellular Component GO:0005788 (endoplasmic reticulum lumen)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO Biological Process GO:0002690 (positive regulation of leukocyte chemotaxis)
GO:0006508 (proteolysis)
GO:0006916 (anti-apoptosis)
GO:0007598 (blood coagulation, extrinsic pathway)
GO:0010641 (positive regulation of platelet-derived growth factor receptor signaling pathway)
GO:0017187 (peptidyl-glutamic acid carboxylation)
GO:0043687 (post-translational protein modification)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0051897 (positive regulation of protein kinase B signaling cascade)
Wikipedia Factor_VII

Target Cross References - Protein

canSAR P08709
CGD Factor VII deficiency
Human Protein Atlas ENSG00000057593
IntAct P08709
Guide to Pharmacology 2363 (coagulation factor VII (serum prothrombin conversion accelerator))
PharmGKB PA160
Reactome REACT_17015 (Metabolism of proteins.)
REACT_24941 (Circadian Clock.)
REACT_604 (Hemostasis.)
UniProt B0YJC8 P08709 Q14339 Q5JVF1 Q5JVF2 Q9UD52 Q9UD53 Q9UD54

Target Cross References - Domain

InterPro IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000294 (GLA_domain.)
IPR000742 (EGF_3.)
IPR001254 (Peptidase_S1_S6.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF_Ca-bd.)
IPR006209 (EGF.)
IPR006210 (EGF-like.)
IPR009003 (Pept_cys/ser_Trypsin-like.)
IPR012224 (Pept_S1A_FX.)
IPR013032 (EGF-like_reg_CS.)
IPR017857 (Coagulation_fac_subgr_Gla_dom.)
IPR018097 (EGF_Ca-bd_CS.)
IPR018114 (Peptidase_S1/S6_AS.)
Pfam PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)

Target Cross References - Structure

PDBe 1CVW 1DAN 1DVA 1FAK 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER More...
CREDO 1CVW 1DAN 1DVA 1FAK 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER More...
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