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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3976
Target Type SINGLE PROTEIN
Preferred Name Dipeptidyl peptidase II
Synonyms DPP II | DPP2 | DPP7 | Dipeptidyl aminopeptidase II | Dipeptidyl peptidase 2 | Dipeptidyl peptidase 7 | Dipeptidyl peptidase II | QPP | Quiescent cell proline dipeptidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sc clan > serine protease s28 family

Target Components

Component Description Relationship Accession
Dipeptidyl peptidase 2 SINGLE PROTEIN Q9UHL4

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111469 Dipeptidyl peptidase II and dipeptidyl peptidase IV (DPP2 and DPP4) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000176978
Ensembl ENSG00000176978
GO Cellular Component GO:0005576 (extracellular region)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0031410 (cytoplasmic vesicle)
GO:0031982 (vesicle)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004177 (aminopeptidase activity)
GO:0004185 (serine-type carboxypeptidase activity)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008239 (dipeptidyl-peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0006508 (proteolysis)
Wikipedia DPP7

Target Cross References - Protein

canSAR Q9UHL4
Human Protein Atlas ENSG00000176978
IntAct Q9UHL4
Guide to Pharmacology 1605
Open Targets ENSG00000176978
PharmGKB PA27469
Reactome R-HSA-6798695 (Neutrophil degranulation.)
UniProt A8K7U7 Q5VSF1 Q969X4 Q9UHL4

Target Cross References - Domain

InterPro IPR008758 (Peptidase_S28.)
IPR029058 (AB_hydrolase.)
Pfam PF05577 (Peptidase_S28)

Target Cross References - Structure

PDBe 3JYH 3N0T 4EBB
CREDO 3JYH 3N0T 4EBB
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