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Target Report Card

Target Name and Classification

Target ID CHEMBL3975
Target Type SINGLE PROTEIN
Preferred Name Fructose-1,6-bisphosphatase
Synonyms D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase 1 | Liver FBPase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Fructose-1,6-bisphosphatase 1 SINGLE PROTEIN P09467

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165140
Ensembl ENSG00000165140
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001191 (transcriptional repressor activity, RNA polymerase II transcription factor binding)
GO:0003824 (catalytic activity)
GO:0005515 (protein binding)
GO:0016208 (AMP binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0042132 (fructose 1,6-bisphosphate 1-phosphatase activity)
GO:0042578 (phosphoric ester hydrolase activity)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0048029 (monosaccharide binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0005975 (carbohydrate metabolic process)
GO:0005986 (sucrose biosynthetic process)
GO:0006000 (fructose metabolic process)
GO:0006002 (fructose 6-phosphate metabolic process)
GO:0006094 (gluconeogenesis)
GO:0006111 (regulation of gluconeogenesis)
GO:0008152 (metabolic process)
GO:0016311 (dephosphorylation)
GO:0030308 (negative regulation of cell growth)
GO:0030388 (fructose 1,6-bisphosphate metabolic process)
GO:0035690 (cellular response to drug)
GO:0045820 (negative regulation of glycolytic process)
GO:0046580 (negative regulation of Ras protein signal transduction)
GO:0051289 (protein homotetramerization)
GO:0071286 (cellular response to magnesium ion)

Target Cross References - Protein

CGD Fructose-1,6-bisphosphatase deficiency
Human Protein Atlas ENSG00000165140
IntAct P09467
Open Targets ENSG00000165140
PharmGKB PA28018
Reactome R-HSA-70263 (Gluconeogenesis.)
UniProt O75571 P09467 Q53F94 Q96E46

Target Cross References - Domain

InterPro IPR000146 (FBPase_class-1.)
IPR020548 (Fructose_bisphosphatase_AS.)
IPR028343 (FBPtase.)
IPR033391 (FBPase_N.)
Pfam PF00316 (FBPase)

Target Cross References - Structure

PDBe 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ
CREDO 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ
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