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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3923
Target Type SINGLE PROTEIN
Preferred Name Nischarin
Synonyms I-1 receptor candidate protein | I-1 | I1R candidate protein | I1R | IR1 | IRAS | Imidazoline receptor 1 | Imidazoline receptor antisera-selected protein | Imidazoline-1 receptor candidate protein | Imidazoline-1 receptor | KIAA0975 | NISCH | Nischarin | hIRAS
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Nischarin SINGLE PROTEIN Q9Y2I1

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL19236 MOXONIDINE Nischarin agonist 4 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000010322
Ensembl ENSG00000010322
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0055037 (recycling endosome)
GO Molecular Function GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0035091 (phosphatidylinositol binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006006 (glucose metabolic process)
GO:0006915 (apoptotic process)
GO:0008217 (regulation of blood pressure)
GO:0016601 (Rac protein signal transduction)
GO:0030036 (actin cytoskeleton organization)
GO:0030336 (negative regulation of cell migration)
GO:0032228 (regulation of synaptic transmission, GABAergic)
GO:0048243 (norepinephrine secretion)
Wikipedia NISCH

Target Cross References - Protein

Human Protein Atlas ENSG00000010322
IntAct Q9Y2I1
Open Targets ENSG00000010322
PharmGKB PA31635
UniProt C9J245 Q6PGP3 Q6PIB4 Q7L8M3 Q7Z2X6 Q9UES6 Q9UEU4 Q9UFW3 Q9Y2I1

Target Cross References - Domain

InterPro IPR001611 (Leu-rich_rpt.)
IPR001683 (Phox.)
IPR032675 (LRR_dom_sf.)
IPR036871 (PX_dom_sf.)
IPR037904 (Nischarin_PX.)
Pfam PF00787 (PX)

Target Cross References - Structure

PDBe 3P0C
CREDO 3P0C
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