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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3911
Preferred Name Leukotriene B4 receptor 1
Synonyms BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LTB4-R 1 | LTB4-R1 | LTB4R | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > leukotriene receptor

Target Components

Component Description Relationship Accession
Leukotriene B4 receptor 1 SINGLE PROTEIN Q15722

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095160 Leukotriene B4 receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL329123 ETALOCIB Leukotriene B4 receptor 1 antagonist 2 DOI PubMed
CHEMBL1742420 AMELUBANT Leukotriene B4 receptor 1 antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213903
Ensembl ENSG00000213903
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001632 (leukotriene B4 receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004974 (leukotriene receptor activity)
GO:0008528 (G-protein coupled peptide receptor activity)
GO Biological Process GO:0006936 (muscle contraction)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0061737 (leukotriene signaling pathway)
Wikipedia Leukotriene_B4_receptor

Target Cross References - Protein

canSAR Q15722
Human Protein Atlas ENSG00000213903
IntAct Q15722
Guide to Pharmacology 267
Open Targets ENSG00000213903
PharmGKB PA30476
Pharos Q15722 (Tchem)
Reactome R-HSA-391906 (Leukotriene receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt Q13305 Q15722 Q53XV5 Q92641 Q9BSU5

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR003981 (Leukotriene_B4_rcpt.)
IPR003983 (Leukotriene_B4_typ-1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)