ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL3902
Preferred Name Glutathione S-transferase Pi
Synonyms FAEES3 | GST class-pi | GST3 | GSTP1 | GSTP1-1 | Glutathione S-transferase P
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Glutathione S-transferase P SINGLE PROTEIN P09211

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2103810 EZATIOSTAT HYDROCHLORIDE Glutathione S-transferase Pi inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000084207
Ensembl ENSG00000084207
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0031982 (vesicle)
GO:0034774 (secretory granule lumen)
GO:0070062 (extracellular exosome)
GO:0097057 (TRAF2-GSTP1 complex)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0004364 (glutathione transferase activity)
GO:0004602 (glutathione peroxidase activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008432 (JUN kinase binding)
GO:0016740 (transferase activity)
GO:0019207 (kinase regulator activity)
GO:0019901 (protein kinase binding)
GO:0035730 (S-nitrosoglutathione binding)
GO:0035731 (dinitrosyl-iron complex binding)
GO:0043295 (glutathione binding)
GO:0070026 (nitric oxide binding)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0002674 (negative regulation of acute inflammatory response)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006749 (glutathione metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0007417 (central nervous system development)
GO:0008152 (metabolic process)
GO:0009636 (response to toxic substance)
GO:0009890 (negative regulation of biosynthetic process)
GO:0010804 (negative regulation of tumor necrosis factor-mediated signaling pathway)
GO:0014003 (oligodendrocyte development)
GO:0031100 (organ regeneration)
GO:0031667 (response to nutrient levels)
GO:0032355 (response to estradiol)
GO:0032691 (negative regulation of interleukin-1 beta production)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0032869 (cellular response to insulin stimulus)
GO:0032872 (regulation of stress-activated MAPK cascade)
GO:0032873 (negative regulation of stress-activated MAPK cascade)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0033591 (response to L-ascorbic acid)
GO:0034599 (cellular response to oxidative stress)
GO:0035726 (common myeloid progenitor cell proliferation)
GO:0035732 (nitric oxide storage)
GO:0043066 (negative regulation of apoptotic process)
GO:0043124 (negative regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043200 (response to amino acid)
GO:0043312 (neutrophil degranulation)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0043409 (negative regulation of MAPK cascade)
GO:0043508 (negative regulation of JUN kinase activity)
GO:0043651 (linoleic acid metabolic process)
GO:0045471 (response to ethanol)
GO:0048147 (negative regulation of fibroblast proliferation)
GO:0051771 (negative regulation of nitric-oxide synthase biosynthetic process)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070664 (negative regulation of leukocyte proliferation)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071364 (cellular response to epidermal growth factor stimulus)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0071460 (cellular response to cell-matrix adhesion)
GO:0071638 (negative regulation of monocyte chemotactic protein-1 production)
GO:0071672 (negative regulation of smooth muscle cell chemotaxis)
GO:0098869 (cellular oxidant detoxification)
GO:1901687 (glutathione derivative biosynthetic process)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
Wikipedia GSTP1

Target Cross References - Protein

canSAR P09211
Human Protein Atlas ENSG00000084207
IntAct P09211
Open Targets ENSG00000084207
PharmGKB PA29028
Reactome R-HSA-156590 (Glutathione conjugation.)
R-HSA-3299685 (Detoxification of Reactive Oxygen Species.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt O00460 P09211 Q15690 Q5TZY3

Target Cross References - Domain

InterPro IPR003082 (GST_pi.)
IPR004045 (Glutathione_S-Trfase_N.)
IPR004046 (GST_C.)
IPR010987 (Glutathione-S-Trfase_C-like.)
IPR036249 (Thioredoxin-like_sf.)
IPR036282 (Glutathione-S-Trfase_C_sf.)
Pfam PF02798 (GST_N)
PF14497 (GST_C_3)

Target Cross References - Structure

PDBe 10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS More...
CREDO 10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS More...