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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL3891
Target Type SINGLE PROTEIN
Preferred Name Calpain 1
Synonyms CANP 1 | CANPL1 | CAPN1 | Calcium-activated neutral proteinase 1 | Calpain mu-type | Calpain-1 catalytic subunit | Calpain-1 large subunit | Cell proliferation-inducing gene 30 protein | Micromolar-calpain | muCANP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > cysteine protease > cysteine protease ca clan > cysteine protease c2 family

Target Components

Component Description Relationship Accession
Calpain-1 catalytic subunit SINGLE PROTEIN P07384

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038466 Calpain1/2 PROTEIN FAMILY
CHEMBL2111357 Calpain 1 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000014216
Ensembl ENSG00000014216
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005764 (lysosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004198 (calcium-dependent cysteine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0008284 (positive regulation of cell proliferation)
GO:0016241 (regulation of macroautophagy)
GO:0022617 (extracellular matrix disassembly)
GO:0032801 (receptor catabolic process)
GO:0043312 (neutrophil degranulation)
GO:0050790 (regulation of catalytic activity)
GO:0060056 (mammary gland involution)
GO:0070268 (cornification)
GO:0097264 (self proteolysis)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
Wikipedia CAPN1

Target Cross References - Protein

canSAR P07384
Human Protein Atlas ENSG00000014216
IntAct P07384
Open Targets ENSG00000014216
PharmGKB PA26057
Reactome R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6809371 (Formation of the cornified envelope.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
UniProt P07384 Q2TTR0 Q6DHV4

Target Cross References - Domain

InterPro IPR000169 (Pept_cys_AS.)
IPR001300 (Peptidase_C2_calpain_cat.)
IPR002048 (EF_hand_dom.)
IPR011992 (EF-hand-dom_pair.)
IPR018247 (EF_Hand_1_Ca_BS.)
IPR022682 (Calpain_domain_III.)
IPR022683 (Calpain_III.)
IPR022684 (Calpain_cysteine_protease.)
IPR029643 (CAPN1.)
IPR033883 (C2_III.)
IPR036213 (Calpain_III_sf.)
Pfam PF00648 (Peptidase_C2)
PF01067 (Calpain_III)
PF13833 (EF-hand_8)

Target Cross References - Structure

PDBe 1ZCM 2ARY
CREDO 1ZCM 2ARY
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