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Target Report Card

Target Name and Classification

Target ID CHEMBL3869
Preferred Name Matrix metalloproteinase 14
Synonyms MMP-14 | MMP-X1 | MMP14 | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix metalloproteinase-14 | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-14 SINGLE PROTEIN P50281

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000157227
Ensembl ENSG00000157227
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005796 (Golgi lumen)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO:0031410 (cytoplasmic vesicle)
GO:0042470 (melanosome)
GO:0044354 (macropinosome)
GO:0045111 (intermediate filament cytoskeleton)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016504 (peptidase activator activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001503 (ossification)
GO:0001525 (angiogenesis)
GO:0001541 (ovarian follicle development)
GO:0001666 (response to hypoxia)
GO:0001935 (endothelial cell proliferation)
GO:0001958 (endochondral ossification)
GO:0006508 (proteolysis)
GO:0006979 (response to oxidative stress)
GO:0008584 (male gonad development)
GO:0009612 (response to mechanical stimulus)
GO:0009725 (response to hormone)
GO:0010831 (positive regulation of myotube differentiation)
GO:0010952 (positive regulation of peptidase activity)
GO:0014070 (response to organic cyclic compound)
GO:0016477 (cell migration)
GO:0016485 (protein processing)
GO:0022617 (extracellular matrix disassembly)
GO:0030307 (positive regulation of cell growth)
GO:0030324 (lung development)
GO:0030335 (positive regulation of cell migration)
GO:0030574 (collagen catabolic process)
GO:0031638 (zymogen activation)
GO:0035987 (endodermal cell differentiation)
GO:0035988 (chondrocyte proliferation)
GO:0043615 (astrocyte cell migration)
GO:0043627 (response to estrogen)
GO:0045579 (positive regulation of B cell differentiation)
GO:0045746 (negative regulation of Notch signaling pathway)
GO:0048701 (embryonic cranial skeleton morphogenesis)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048771 (tissue remodeling)
GO:0048870 (cell motility)
GO:0051895 (negative regulation of focal adhesion assembly)
GO:0060322 (head development)
GO:0060348 (bone development)
GO:0097094 (craniofacial suture morphogenesis)
GO:1905523 (positive regulation of macrophage migration)
GO:1990834 (response to odorant)
Wikipedia MMP14

Target Cross References - Protein

Human Protein Atlas ENSG00000157227
IntAct P50281
Guide to Pharmacology 1638
Open Targets ENSG00000157227
PharmGKB PA30872
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
UniProt A8K5L0 P50281 Q6GSF3 Q92678

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR021805 (Pept_M10A_metallopeptidase_C.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR028693 (MMP14.)
IPR033739 (M10A_MMP.)
IPR036365 (PGBD-like_sf.)
IPR036366 (PGBDSf.)
IPR036375 (Hemopexin-like_dom_sf.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
PF11857 (DUF3377)

Target Cross References - Structure

PDBe 1BQQ 1BUV 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U
CREDO 1BQQ 1BUV 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U