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Target Report Card

Target Name and Classification

Target ID CHEMBL3859
Preferred Name Cytochrome P450 19A1
Synonyms Arom | Aromatase | CYPXIX | Cyp19 | Cyp19a1 | Cytochrome P-450AROM | Cytochrome P450 19A1 | Estrogen synthase
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 19 > cytochrome p450 family 19a > cytochrome p450 19a1

Target Components

Component Description Relationship Accession
Aromatase SINGLE PROTEIN P22443

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043197 (dendritic spine)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0001553 (luteinization)
GO:0006703 (estrogen biosynthetic process)
GO:0008206 (bile acid metabolic process)
GO:0008207 (C21-steroid hormone metabolic process)
GO:0008209 (androgen metabolic process)
GO:0008584 (male gonad development)
GO:0009635 (response to herbicide)
GO:0010038 (response to metal ion)
GO:0010164 (response to cesium ion)
GO:0010212 (response to ionizing radiation)
GO:0014070 (response to organic cyclic compound)
GO:0018879 (biphenyl metabolic process)
GO:0018894 (dibenzo-p-dioxin metabolic process)
GO:0018963 (phthalate metabolic process)
GO:0021766 (hippocampus development)
GO:0021854 (hypothalamus development)
GO:0030186 (melatonin metabolic process)
GO:0030325 (adrenal gland development)
GO:0030851 (granulocyte differentiation)
GO:0032355 (response to estradiol)
GO:0033574 (response to testosterone)
GO:0042493 (response to drug)
GO:0043278 (response to morphine)
GO:0043627 (response to estrogen)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0045779 (negative regulation of bone resorption)
GO:0050803 (regulation of synapse structure or activity)
GO:0055114 (oxidation-reduction process)
GO:0060348 (bone development)
GO:0071333 (cellular response to glucose stimulus)
GO:0071371 (cellular response to gonadotropin stimulus)
GO:0071372 (cellular response to follicle-stimulating hormone stimulus)
GO:0071464 (cellular response to hydrostatic pressure)
GO:0097720 (calcineurin-mediated signaling)

Target Cross References - Protein

canSAR P22443
MICAD NBK23196 (Aromatase)
UniProt P22443

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
IPR036396 (Cyt_P450_sf.)
Pfam PF00067 (p450)