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Target Report Card

Target Name and Classification

Target ID CHEMBL3819
Preferred Name Lysophosphatidic acid receptor Edg-2
Synonyms EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | Lysophosphatidic acid receptor 1 | Lysophosphatidic acid receptor Edg-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > edg receptor

Target Components

Component Description Relationship Accession
Lysophosphatidic acid receptor 1 SINGLE PROTEIN Q92633

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885601 Lysophosphatidic acid receptor 1/3 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198121
Ensembl ENSG00000198121
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030139 (endocytic vesicle)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008289 (lipid binding)
GO:0030165 (PDZ domain binding)
GO:0035727 (lysophosphatidic acid binding)
GO:0070915 (lysophosphatidic acid receptor activity)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007420 (brain development)
GO:0008360 (regulation of cell shape)
GO:0010942 (positive regulation of cell death)
GO:0010977 (negative regulation of neuron projection development)
GO:0014003 (oligodendrocyte development)
GO:0021549 (cerebellum development)
GO:0021554 (optic nerve development)
GO:0022008 (neurogenesis)
GO:0022038 (corpus callosum development)
GO:0032060 (bleb assembly)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0042552 (myelination)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0060326 (cell chemotaxis)
GO:0060999 (positive regulation of dendritic spine development)
GO:0071453 (cellular response to oxygen levels)
GO:0071673 (positive regulation of smooth muscle cell chemotaxis)
GO:1904566 (cellular response to 1-oleoyl-sn-glycerol 3-phosphate)
Wikipedia LPAR1

Target Cross References - Protein

canSAR Q92633
Human Protein Atlas ENSG00000198121
IntAct Q92633
Guide to Pharmacology 272
Open Targets ENSG00000198121
PharmGKB PA162394187
Pharos Q92633 (Tchem)
Reactome R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-419408 (Lysosphingolipid and LPA receptors.)
UniProt B4DK36 O00656 O00722 P78351 Q92633

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002277 (LPA_rcpt_EDG2.)
IPR004065 (LPA_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4Z34 4Z35 4Z36
CREDO 4Z34 4Z35 4Z36