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Target Report Card

Target Name and Classification

Target ID CHEMBL3816
Target Type SINGLE PROTEIN
Preferred Name Cytosolic phospholipase A2
Synonyms CPLA2 | Cytosolic phospholipase A2 | Lysophospholipase | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IVA | Phospholipase A2 | cPLA2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Cytosolic phospholipase A2 SINGLE PROTEIN P47712

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116711
Ensembl ENSG00000116711
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005743 (mitochondrial inner membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0031410 (cytoplasmic vesicle)
GO:0042588 (zymogen granule)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0004620 (phospholipase activity)
GO:0004622 (lysophospholipase activity)
GO:0004623 (phospholipase A2 activity)
GO:0005509 (calcium ion binding)
GO:0005544 (calcium-dependent phospholipid binding)
GO:0008970 (phosphatidylcholine 1-acylhydrolase activity)
GO:0016787 (hydrolase activity)
GO:0035035 (histone acetyltransferase binding)
GO:0046872 (metal ion binding)
GO:0047498 (calcium-dependent phospholipase A2 activity)
GO Biological Process GO:0001542 (ovulation from ovarian follicle)
GO:0001554 (luteolysis)
GO:0006629 (lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0006663 (platelet activating factor biosynthetic process)
GO:0006690 (icosanoid metabolic process)
GO:0007568 (aging)
GO:0008152 (metabolic process)
GO:0008284 (positive regulation of cell proliferation)
GO:0009395 (phospholipid catabolic process)
GO:0009408 (response to heat)
GO:0009725 (response to hormone)
GO:0010033 (response to organic substance)
GO:0010226 (response to lithium ion)
GO:0010243 (response to organonitrogen compound)
GO:0016042 (lipid catabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0030501 (positive regulation of bone mineralization)
GO:0031340 (positive regulation of vesicle fusion)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031622 (positive regulation of fever generation)
GO:0032496 (response to lipopolysaccharide)
GO:0033280 (response to vitamin D)
GO:0035965 (cardiolipin acyl-chain remodeling)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
GO:0042127 (regulation of cell proliferation)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043129 (surfactant homeostasis)
GO:0046456 (icosanoid biosynthetic process)
GO:0046697 (decidualization)
GO:0050482 (arachidonic acid secretion)
GO:0050729 (positive regulation of inflammatory response)
GO:0051384 (response to glucocorticoid)
GO:0051592 (response to calcium ion)
GO:0051597 (response to methylmercury)
GO:0071236 (cellular response to antibiotic)
Wikipedia PLA2G4A

Target Cross References - Protein

CGD Phospholipase A2, group IV A, deficiency of
Human Protein Atlas ENSG00000116711
IntAct P47712
Guide to Pharmacology 1424
Open Targets ENSG00000116711
PharmGKB PA271
Reactome R-HSA-111995 (phospho-PLA2 pathway.)
R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482798 (Acyl chain remodeling of CL.)
R-HSA-1482801 (Acyl chain remodelling of PS.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-1482922 (Acyl chain remodelling of PI.)
R-HSA-1482925 (Acyl chain remodelling of PG.)
R-HSA-1483115 (Hydrolysis of LPC.)
R-HSA-1483166 (Synthesis of PA.)
R-HSA-2142753 (Arachidonic acid metabolism.)
R-HSA-418592 (ADP signalling through P2Y purinoceptor 1.)
R-HSA-432142 (Platelet sensitization by LDL.)
R-HSA-6811436 (COPI-independent Golgi-to-ER retrograde traffic.)
UniProt B1AKG4 P47712 Q29R80

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR002642 (LysoPLipase_cat_dom.)
IPR016035 (Acyl_Trfase/lysoPLipase.)
Pfam PF00168 (C2)
PF01735 (PLA2_B)

Target Cross References - Structure

PDBe 1CJY 1RLW
CREDO 1CJY 1RLW
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