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Target Report Card

Target Name and Classification

Target ID CHEMBL3807
Target Type SINGLE PROTEIN
Preferred Name T-cell protein-tyrosine phosphatase
Synonyms PTPN2 | PTPT | T-cell protein-tyrosine phosphatase | TCPTP | Tyrosine-protein phosphatase non-receptor type 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
Tyrosine-protein phosphatase non-receptor type 2 SINGLE PROTEIN P17706

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175354
Ensembl ENSG00000175354
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005793 (endoplasmic reticulum-Golgi intermediate compartment)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0004726 (non-membrane spanning protein tyrosine phosphatase activity)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019901 (protein kinase binding)
GO:0019905 (syntaxin binding)
GO:0030971 (receptor tyrosine kinase binding)
GO:0097677 (STAT family protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006470 (protein dephosphorylation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0010804 (negative regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010888 (negative regulation of lipid storage)
GO:0016311 (dephosphorylation)
GO:0030183 (B cell differentiation)
GO:0030217 (T cell differentiation)
GO:0030218 (erythrocyte differentiation)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0042532 (negative regulation of tyrosine phosphorylation of STAT protein)
GO:0042593 (glucose homeostasis)
GO:0045650 (negative regulation of macrophage differentiation)
GO:0045722 (positive regulation of gluconeogenesis)
GO:0046627 (negative regulation of insulin receptor signaling pathway)
GO:0050728 (negative regulation of inflammatory response)
GO:0050860 (negative regulation of T cell receptor signaling pathway)
GO:0050922 (negative regulation of chemotaxis)
GO:0060334 (regulation of interferon-gamma-mediated signaling pathway)
GO:0060336 (negative regulation of interferon-gamma-mediated signaling pathway)
GO:0060339 (negative regulation of type I interferon-mediated signaling pathway)
GO:0061099 (negative regulation of protein tyrosine kinase activity)
GO:0070104 (negative regulation of interleukin-6-mediated signaling pathway)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0071345 (cellular response to cytokine stimulus)
GO:1902202 (regulation of hepatocyte growth factor receptor signaling pathway)
GO:1902206 (negative regulation of interleukin-2-mediated signaling pathway)
GO:1902215 (negative regulation of interleukin-4-mediated signaling pathway)
GO:1902227 (negative regulation of macrophage colony-stimulating factor signaling pathway)
GO:1902233 (negative regulation of positive thymic T cell selection)
GO:1902237 (positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1903899 (positive regulation of PERK-mediated unfolded protein response)
GO:2000587 (negative regulation of platelet-derived growth factor receptor-beta signaling pathway)
Wikipedia PTPN2

Target Cross References - Protein

canSAR P17706
Human Protein Atlas ENSG00000175354
IntAct P17706
Open Targets ENSG00000175354
PharmGKB PA33993
Reactome R-HSA-6807004 (Negative regulation of MET activity.)
R-HSA-877312 (Regulation of IFNG signaling.)
R-HSA-9008059 (Interleukin-37 signaling.)
UniProt A8K955 A8MXU3 K7ENG3 P17706 Q96AU5 Q96HR2

Target Cross References - Domain

InterPro IPR000242 (PTPase_domain.)
IPR000387 (TYR_PHOSPHATASE_dom.)
IPR003595 (Tyr_Pase_cat.)
IPR012265 (Ptpn1/Ptpn2.)
IPR016130 (Tyr_Pase_AS.)
IPR029021 (Prot-tyrosine_phosphatase-like.)
Pfam PF00102 (Y_phosphatase)

Target Cross References - Structure

PDBe 1L8K
CREDO 1L8K
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