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Target Report Card

Target Name and Classification

Target ID CHEMBL3775
Target Type SINGLE PROTEIN
Preferred Name Dual specificity phosphatase Cdc25A
Synonyms CDC25A | Dual specificity phosphatase Cdc25A | M-phase inducer phosphatase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphatase > protein phosphatase > serine/threonine/tyrosine protein phosphatase

Target Components

Component Description Relationship Accession
M-phase inducer phosphatase 1 SINGLE PROTEIN P30304

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164045
Ensembl ENSG00000164045
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004721 (phosphoprotein phosphatase activity)
GO:0004725 (protein tyrosine phosphatase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0019901 (protein kinase binding)
GO:0051087 (chaperone binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006260 (DNA replication)
GO:0006470 (protein dephosphorylation)
GO:0007049 (cell cycle)
GO:0008283 (cell proliferation)
GO:0009314 (response to radiation)
GO:0016579 (protein deubiquitination)
GO:0034644 (cellular response to UV)
GO:0035335 (peptidyl-tyrosine dephosphorylation)
GO:0051301 (cell division)
GO:0051726 (regulation of cell cycle)
GO:1902751 (positive regulation of cell cycle G2/M phase transition)
Wikipedia CDC25A

Target Cross References - Protein

canSAR P30304
Human Protein Atlas ENSG00000164045
IntAct P30304
Open Targets ENSG00000164045
PharmGKB PA26259
Reactome R-HSA-1362277 (Transcription of E2F targets under negative control by DREAM complex.)
R-HSA-156711 (Polo-like kinase mediated events.)
R-HSA-176187 (Activation of ATR in response to replication stress.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-69202 (Cyclin E associated events during G1/S transition.)
R-HSA-69273 (Cyclin A/B1/B2 associated events during G2/M transition.)
R-HSA-69601 (Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.)
R-HSA-69656 (Cyclin A:Cdk2-associated events at S phase entry.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
UniProt P30304 Q8IZH5 Q96IL3 Q9H2F2

Target Cross References - Domain

InterPro IPR000751 (MPI_Phosphatase.)
IPR001763 (Rhodanese-like_dom.)
IPR036873 (Rhodanese-like_dom_sf.)
Pfam PF00581 (Rhodanese)
PF06617 (M-inducer_phosp)

Target Cross References - Structure

PDBe 1C25
CREDO 1C25
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